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Relationship of Genetic Markers for Atherosclerosis and Long-Term Outcome after Percutaneous Coronary Intervention with Stenting

Robert Bernat ; »J. J. Strossmayer« University, »Magdalena« Clinic for Cardiovascular Diseases, Department of Cardiology, Krapinske Toplice,
Janko Szavits-Nossan ; »J. J. Strossmayer« University, »Magdalena« Clinic for Cardiovascular Diseases, Department of Cardiology, Krapinske Toplice,
Aleksandar Trbovic ; »J. J. Strossmayer« University, »Magdalena« Clinic for Cardiovascular Diseases, Department of Cardiology, Krapinske Toplice,
Ksenija Kapov-Svilicic ; »J. J. Strossmayer« University, »Magdalena« Clinic for Cardiovascular Diseases, Department of Cardiology, Krapinske Toplice,
Igor Sesto ; »J. J. Strossmayer« University, »Magdalena« Clinic for Cardiovascular Diseases, Department of Cardiology, Krapinske Toplice,
Tomislav Sipic ; »J. J. Strossmayer« University, »Magdalena« Clinic for Cardiovascular Diseases, Department of Cardiology, Krapinske Toplice,

Puni tekst: engleski, pdf (123 KB) str. 1385-1390 preuzimanja: 249* citiraj
APA 6th Edition
Bernat, R., Szavits-Nossan, J., Trbovic, A., Kapov-Svilicic, K., Sesto, I. i Sipic, T. (2012). Relationship of Genetic Markers for Atherosclerosis and Long-Term Outcome after Percutaneous Coronary Intervention with Stenting. Collegium antropologicum, 36 (4), 1385-1390. Preuzeto s https://hrcak.srce.hr/94961
MLA 8th Edition
Bernat, Robert, et al. "Relationship of Genetic Markers for Atherosclerosis and Long-Term Outcome after Percutaneous Coronary Intervention with Stenting." Collegium antropologicum, vol. 36, br. 4, 2012, str. 1385-1390. https://hrcak.srce.hr/94961. Citirano 14.08.2020.
Chicago 17th Edition
Bernat, Robert, Janko Szavits-Nossan, Aleksandar Trbovic, Ksenija Kapov-Svilicic, Igor Sesto i Tomislav Sipic. "Relationship of Genetic Markers for Atherosclerosis and Long-Term Outcome after Percutaneous Coronary Intervention with Stenting." Collegium antropologicum 36, br. 4 (2012): 1385-1390. https://hrcak.srce.hr/94961
Harvard
Bernat, R., et al. (2012). 'Relationship of Genetic Markers for Atherosclerosis and Long-Term Outcome after Percutaneous Coronary Intervention with Stenting', Collegium antropologicum, 36(4), str. 1385-1390. Preuzeto s: https://hrcak.srce.hr/94961 (Datum pristupa: 14.08.2020.)
Vancouver
Bernat R, Szavits-Nossan J, Trbovic A, Kapov-Svilicic K, Sesto I, Sipic T. Relationship of Genetic Markers for Atherosclerosis and Long-Term Outcome after Percutaneous Coronary Intervention with Stenting. Collegium antropologicum [Internet]. 2012 [pristupljeno 14.08.2020.];36(4):1385-1390. Dostupno na: https://hrcak.srce.hr/94961
IEEE
R. Bernat, J. Szavits-Nossan, A. Trbovic, K. Kapov-Svilicic, I. Sesto i T. Sipic, "Relationship of Genetic Markers for Atherosclerosis and Long-Term Outcome after Percutaneous Coronary Intervention with Stenting", Collegium antropologicum, vol.36, br. 4, str. 1385-1390, 2012. [Online]. Dostupno na: https://hrcak.srce.hr/94961. [Citirano: 14.08.2020.]

Sažetak
The aim of the study was to describe the relationship of clinical outcome after percutaneous coronary intervention (PCI) with stenting and genetic polymorphisms (GP) which are known to relate to the incidence of in-stent restenosis and late thrombotic complications. The study included 190 patients with standardized clinical follow-up over 5 years, which were initially treated with PCI. We investigated clinical data, angiographic characteristics, 10 polymorphisms involved in neointimal hyperplasia and late thrombosis at 6 different levels and their relationship with the major adverse cardiac events (MACE). The long term clinical outcome was defined by MACE: death, target vessel revascularization (PCI or coronary bypass grafting, CABG) and myocardial infarction. Angiotensin receptor type I (AGTR A1166C) and angiotensinogen (AGT MET235THR) GPs correlated with repeat revascularization and total MACE. Carriers of G allele for NOS3 A922G GP were shown to have a significantly lower repeat revascularization rate in comparison with the AA genotype, as did the T allele carriers in the NOS3 C690T GP analysis when compared to the CC genotype. The Asp genome carriers with the NOS3 GLU298ASP GP were also shown to have significantly less re-PCI in contrast to the Glu/Glu genotype. The study could document the protective influence of the 4G/5G GP for plasminogen inhibitor activator-1, which carried the lowest rate of re-PCI and total MACE during the follow-up. GPs for b-1 G-protein subunit GNB3 C825T, fibrinogen FGB G455A and E-selectins Ser128Arg and Leu554Phe did not show statistical correlation with the clinical outcome. The results illustrate the potential use of genetic markers in defining patients with possibly worse clinical outcome after PCI, who may profit from more aggressive prevention of restenosis and late thrombotic complications.

Ključne riječi
genetic markers; percutaneous coronary intervention; stent; restenosis; late stent thrombosis; clinical outcome

Hrčak ID: 94961

URI
https://hrcak.srce.hr/94961

Posjeta: 433 *