Izvorni znanstveni članak

https://doi.org/10.5599/jese.2012.0026

Electrochemical investigations of unexplored anthraquinones and their DNA binding

Afzal Shah ; Department of Chemistry, Quaid-i-Azam University, 45320, Islamabad, Pakistan; National Center of Excellence in Analytical Chemistry, University of Sindh, Jamshoro, Pakistan
Abdur Rauf ; Department of Chemistry, Quaid-i-Azam University, 45320, Islamabad, Pakistan; National Center of Excellence in Analytical Chemistry, University of Sindh, Jamshoro, Pakistan
Asad Ullah ; Department of Chemistry, Quaid-i-Azam University, 45320, Islamabad, Pakistan; National Center of Excellence in Analytical Chemistry, University of Sindh, Jamshoro, Pakistan
Azeema Munir ; Department of Chemistry, Quaid-i-Azam University, 45320, Islamabad, Pakistan; National Center of Excellence in Analytical Chemistry, University of Sindh, Jamshoro, Pakistan
Romana Qureshi ; Department of Chemistry, Quaid-i-Azam University, 45320, Islamabad, Pakistan; National Center of Excellence in Analytical Chemistry, University of Sindh, Jamshoro, Pakistan
Iftikhar Ahmad ; Department of Chemistry, Quaid-i-Azam University, 45320, Islamabad, Pakistan; National Center of Excellence in Analytical Chemistry, University of Sindh, Jamshoro, Pakistan
Muhammad Tahir Soomro ; Department of Chemistry, Quaid-i-Azam University, 45320, Islamabad, Pakistan; National Center of Excellence in Analytical Chemistry, University of Sindh, Jamshoro, Pakistan
Zia-Ur Rehman ; Department of Chemistry, Quaid-i-Azam University, 45320, Islamabad, Pakistan; National Center of Excellence in Analytical Chemistry, University of Sindh, Jamshoro, Pakistan

Sažetak

The redox behaviour of two potential anticancer anthraquinones, 9,10-anthraquinone and 2-chloromethyl-9,10-anthraquinone was investigated in a wide pH range. Cyclic voltammetry based assay was developed for the assessment of the effect of medium, substituents, potential scan rate and number of scans on the voltammetric response of anthraquinones. The electrode reaction mechanism was suggested on the basis of cyclic and differential pulse voltammetric results. The effect of DNA on anthraquinones was also probed at physiological pH which could lead to further investigation of possible citotoxic activity in vitro. The results revealed that anthraquinones interact with DNA more strongly than the clinically used anticancer drug, epirubicin.

Ključne riječi

Anthraquinones; redox mechanism; voltammetry; binding constant

Hrčak ID:

96898

URI

https://hrcak.srce.hr/96898

Datum izdavanja:

6.2.2013.

Posjeta: 1.928 *