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Biomechanical Properties of Bones from Rats Treated with Sevelamer

Natasa Drača
Ana Tikvica
Domagoj Eljuga
Damir Semenski
Mladen Brnčić
Slobodan Vukičević

Puni tekst: engleski pdf 379 Kb

str. 557-563

preuzimanja: 356



Sevelamer hydrochloride is used for ten years in patients on dialysis as a phosphate binder.We have previously shown
that oral application of sevelamer prevents the bone loss and increases the bone volume in ovariectomized rats1. In this
study we further analysed the biomechanical properties of bones from rats treated with sevelamer utilizing a threepoint
bending test to determine the mechanical properties of the cortical bone of the mid-shaft femur, while the indentation test
was used to determine the mechanical properties of cancellous bone in the marrow cavity of the distal femoral metaphysis.
Parameters analyzed included: maximum load (Fu), stiffness (S), energy absorbed (W), toughness (T) and ultimate
strength (s). The intrinsic properties, stress, elastic modulus and toughness were determined from measured maximum
load, strains, stiffness, energy absorbed, outer and inner diameters, and calculated bone cross-sectional moment of
inertia. Sevelamer was given to rats for 25 weeks with a content of 3% of sevelamer in a standard diet, starting immediately
following ovariectomy (OVX). Animals were divided to the following groups: (1) Sham; (2) Sham + sevelamer 3%;
(3) OVX; (4) OVX + sevelamer 3%. Our results showed that sevelamer particularly influenced the rat trabecular bone by
increasing the maximum load for 26.2%, energy absorbed for 24.2% and the ultimate strength for 26.2% in sham animals
treated with sevelamer 3%, as compared to sham rats. Sevelamer 3% in OVX rats also increased the maximum load
for 71.4%, stiffness for 70.7%, energy absorbed for 55.9% and the ultimate strength for 71.3% as compared to OVX controls.
In the three bending test sevelamer had a very little effect on preventing loss of bone strenght in the cortical bone.
These results collectively suggest that sevelamer improves bone biomechanical properties, mainly affecting trabecular
bone quality in both normal and ovariectomized rats.

Ključne riječi

biomechanical testing, threepoint bending test, indentation test, bone

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