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Diffuse Sclerosing Variant of Thyroid Carcinoma Presenting as Hashimoto Thyroiditis: A Case Report

Anamarija Vukasović ; Department of Nuclear Medicine, Dubrava University Hospital, Zagreb, Croatia
Sanja Kusačić Kuna ; Department of Nuclear Medicine and Radiation Protection, Clinical Hospital Centre Zagreb, Zagreb,Croatia
Karmen Trutin Ostović ; Department of Clinical Cytology and Cytometry, Dubrava University Hospital, Zagreb, Croatia
Drago Prgomet ; Department of Otorhinolaryngology, Head and Neck Surgery, Clinical Hospital Centre Zagreb, Zagreb, Croatia
Tomislav Banek ; Department of Nuclear Medicine, Dubrava University Hospital, Zagreb, Croatia

Puni tekst: engleski pdf 151 Kb

str. 219-221

preuzimanja: 372



The aim of report is to present a case of a rare diffuse sclerosing variant of a papillary thyroid carcinoma. A 15- year old girl referred for ultrasound examination because of painless thyroid swelling lasting 10 days before. An ultrasound of the neck showed diffusely changed thyroid parenchyma, without nodes, looking as lymphocytic thyroiditis Hashimoto at first, but with »snow-storm« appearance, predominantly in the right lobe. Positive thyroid peroxidase antibodies
(TPO-AT) also suggested Hashimoto thyroiditis. Repeated US-FNAB (fine needle-aspiration biopsy) of the right lobe revealed diffuse sclerosing variant of papillary thyroid carcinoma and patient underwent total thyreoidectomy. Patohistologic finding confirmed diffuse sclerosing variant of a papillary thyroid carcinoma in the both thyroid lobes and several metastatic lymph nodes. Two months later patient recived radioablative therapy with 3700 MBq (100 mCi) of I-131 followed by levothyroxine replacement. At the moment, patient is without evidence of local or distant metastases and next regular control is scheduled in 6 months. In conclusion, a diffuse sclerosing variant is rare form of papillary thyroid carcinoma that echographically looks similar to Hashimoto thyroiditis and sometimes could be easily overlooked.

Ključne riječi

diffuse sclerosing variant, papillary thyroid carcinoma, Hashimoto thyroiditis, neck ultrasound

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