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https://doi.org/10.2478/10004-1254-64-2013-2248

Melatonin Improves Liver Function in Benzene-treated Rats

Seema Sharma ; Toxicology Laboratory, Department of Zoology, Ch. Charan Singh University Meerut, Meerut, India
Suresh Vir Singh Rana ; Toxicology Laboratory, Department of Zoology, Ch. Charan Singh University Meerut, Meerut, India


Puni tekst: engleski pdf 77 Kb

str. 219-226

preuzimanja: 776

citiraj


Sažetak

In this study, we investigated the beneficial effects of melatonin against benzene-induced liver function impairments in Wistar rats. After 30 days of treatment, it significantly lowered hepatosomatic indices, bilirubin, and hydroxyproline in male and female benzene-treated rats. Even though it did not influence aspartate aminotransferase, melatonin had beneficial effects on alanine aminotransferase and alkaline phosphatase. Our results suggest that melatonin is an effective modulator of liver function in benzenetreated rats thanks to its antioxidative properties.

Ključne riječi

alkaline phosphatase, antioxidants, bilirubin, hydroxyproline, serum transaminases

Hrčak ID:

103928

URI

https://hrcak.srce.hr/103928

Podaci na drugim jezicima: hrvatski

Posjeta: 1.156 *