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https://doi.org/10.2478/10004-1254-64-2013-2378

Fresh Frozen Plasma as a Successful Antidotal Supplement in Acute Organophosphate Poisoning

Slavica Vučinić ; National Poison Control Centre, Medical Faculty, Military Medical Academy, University of Defence, Belgrade, Serbia
Milica Zlatković ; National Poison Control Centre, Medical Faculty, Military Medical Academy, University of Defence, Belgrade, Serbia
Biljana Antonijević ; Department of Toxicology “Akademik Danilo Soldatović”, Faculty of Pharmacy, University of Belgrade, Belgrade, Se
Marijana Ćuričić ; Department of Toxicology “Akademik Danilo Soldatović”, Faculty of Pharmacy, University of Belgrade, Belgrade, Se
Bogdan Bošković ; National Poison Control Centre, Medical Faculty, Military Medical Academy, University of Defence, Belgrade, Serbia


Puni tekst: engleski pdf 68 Kb

str. 273-276

preuzimanja: 901

citiraj


Sažetak

Despite improvements to intensive care management and specific pharmacological treatments (atropine, oxime, diazepam), the mortality associated with organophosphate (OP) poisoning has not substantially decreased. The objective of this examination was to describe the role of fresh frozen plasma (FFP) in acute OP poisoning. After a deliberate ingestion of malathion, a 55-year-old male suffering from miosis, somnolence, bradycardia, muscular fasciculations, rales on auscultation, respiratory insufficiency, as well as from an inhibition of red blood cell acetylcholinesterase (AChE) and plasma butyrylcholinesterase (BuChE), was admitted to hospital. Malathion was confirmed in a concentration of 18.01 mg L-1. Apart from supportive measures (including mechanical ventilation for four days), antidotal treatment with atropine, oxime - pralidoxime methylsulphate (Contrathion®), and diazepam was administered, along with FFP. The potentially beneficial effects of FFP therapy included a prompt increase of BuChE activity (from 926 IU L-1 to 3277 IU L-1; reference range from 7000 IU L-1 to 19000 IU L-1) and a reduction in the malathion concentration, followed by clinical recovery. Due to BuChE replacement, albumin content, and volume restitution, FFP treatment may be used as an alternative approach in patients with acute OP poisoning, especially when oximes are not available.

Ključne riječi

acetylcholinesterases, albumin, butyrylcholinesterase, malathion, oximes

Hrčak ID:

103937

URI

https://hrcak.srce.hr/103937

Podaci na drugim jezicima: hrvatski

Posjeta: 1.631 *