Izvorni znanstveni članak

https://doi.org/10.5599/admet.2.2.34

A physiologically-oriented mathematical model for the description of in vivo drug release and absorption

Renzo Del Cont ; Dept. of Engineering and Architecture, Trieste University, Via Alfonso Valerio, 6/A, Trieste, I-34127 Italy
Michela Abrami ; Dept. of Engineering and Architecture, Trieste University, Via Alfonso Valerio, 6/A, Trieste, I-34127 Italy
Dritan Hasa ; Dept. of Chemical and Pharmaceutical Sciences, Trieste University, Piazzale Europa 1, Trieste, I-34127, Italy
Beatrice Perissutti ; Dept. of Chemical and Pharmaceutical Sciences, Trieste University, Piazzale Europa 1, Trieste, I-34127, Italy
Dario Voinovich ; Dept. of Chemical and Pharmaceutical Sciences, Trieste University, Piazzale Europa 1, Trieste, I-34127, Italy
Anna Barba ; Dept. of Pharmacy, Salerno University, Via Giovanni Paolo II, 132, Fisciano (SA), I 84084 Italy
Gaetano Lamberti ; Dept. of Industrial Engineering, Salerno University, Via Giovanni Paolo II, 132, Fisciano (SA), I 84084 Italy
Gabriele Grassi ; Dept. of Life Sciences, Cattinara University Hospital, Trieste University, Strada di Fiume 447, Trieste, I-34149 Italy
Italo Colombo ; Dept. of Engineering and Architecture, Trieste University, Via Alfonso Valerio, 6/A, Trieste, I-34127 Italy
Davide Manca ; Dept. of Chemistry, Materials and Chemical Engineering "Giulio Natta" Politecnico di Milano, P.zza Leonardo Da Vinci, 32 – Milano, I-20133 Italy
Mario Grassi orcid.org/0000-0002-3532-3200 ; Dept. of Engineering and Architecture, Trieste University, Via Alfonso Valerio, 6/A, Trieste, I-34127 Italy

Sažetak

This paper focuses on a physiologically-oriented mathematical model aimed at studying the in vivo drug release, absorption, distribution, metabolism and elimination (ADME). To this purpose, the model accounts for drug delivery from an ensemble of non-eroding poly-disperse polymeric particles and the subsequent ADME processes. The model outcomes are studied with reference to three widely used drugs: theophylline, temazepam and nimesulide. One of the most important results of this study is the quantitative evaluation of the interplay between the release kinetics and the subsequent ADME processes. Indeed, it is usually assumed that in vivo drug release coincides with in vitro so that the effect exerted by the ADME processes is neglected. In addition, the proposed model may be an important tool for the design of delivery systems since, through proper changes, it could also account for different oral delivery systems.

Ključne riječi

Mathematical modelling; in vitro release; in vivo release; pharmacokinetics

Hrčak ID:

125174

URI

https://hrcak.srce.hr/125174

Datum izdavanja:

18.7.2014.

Posjeta: 1.749 *