Reumatizam, Vol. 55 No. 1, 2008.
Izvorni znanstveni članak
Diagnostic and therapeutic approach to pregnant women suspect on antiphospholipid syndrome
Marija Glasnović
; Klinički odjel za reumatologiju, imunologiju i alergologiju, Klinika za internu medicinu, Klinička bolnica Osijek, Osijek, Hrvatska
Ivica Bošnjak
; Klinički odjel za bolesti srca i krvnih žila s intenzivnim liječenjem, Klinika za internu medicinu, Klinička bolnica Osijek, Osijek, Hrvatska
Aleksandar Včev
; Klinički odjel za gastroenterologiju, Klinika za internu medicinu, Klinička bolnica Osijek, Osijek, Hrvatska
Maja Košuta
; Odjel za ginekologiju i opstetriciju, Klinička bolnica Osijek, Osijek, Hrvatska
Bahrija Lenz
; Odjel za transfuzijsku medicinu, Klinička bolnica Osijek, Osijek, Hrvatska
Elizabeta Glasnović-Horvatić
; Odjel za patološku anatomiju, Opća bolnica “dr. Tomislav Bardek”, Koprivnica, Hrvatska
Sažetak
Antiphospholipid syndrome includes the presence of antiphospholipid antibodies, vascular thrombosis and reproductive function disturbances. The aim was to show our diagnostic and therapeutic experiences. 62 women were included in study, 32 with primary antiphospholipd syndrome (PAPS), and 30 with secondary antiphospholipid syndrome (SAPS). 36 were pregnant and studied prospectively throughout pregnancy and six weeks after the delivery. Lupus-anticoagulant (LA) was positive in 23 patients with PAPS (71.9%), and in 10 patients with SAPS (33.3%). In SAPS group anticardiolipin antibodies (aCL) was positive in 8 patients (26.6%) compared to PAPS group with 3 aCL positive patients (9.4%). Antibeta2glycoprotein1 (antiβ2GP1) was positive in 3 patients with PAPS. Complications in previous pregnancies were in 25 cases (69.4%) spontaneous abortion, in 7 cases (19.4%) preeclampsia with intrauterine growth restriction (IUGR) in 3 patients. In 4 cases the complication was fetal death in utero. Average pregnancy lasted 37,06±0,707 weeks. Therapy with low dose aspirin and low-molecular-weight heparin was successful in 97.2%.
Ključne riječi
antiphospholipid syndrome; pregnant women; antibodies
Hrčak ID:
125314
URI
Datum izdavanja:
1.7.2008.
Posjeta: 2.319 *