Stručni rad

Anticonvulsant induced metabolic disorder - case report

Dušanka Martinović Kaliterna ; Odsjek za kliničku imunologiju i reumatologiju, Klinika za unutarnje bolesti, Klinički bolnički centar Split, Split, Hrvatska
Zrinka Jurišić ; Odjel za kardiologiju, Klinika za unutarnje bolesti, Klinički bolnički centar Split, Split, Hrvatska

Sažetak

Osteomalacia, metabolic bone disease in the adults, is disorder in which mineralization of the organic matrix of the skeleton is defective. This disorder is caused by a number of different conditions associated with alterations of vitamin D metabolism. Anticonvulsant therapy can also cause the development of osteomalacia due to alteration of vitamin D metabolism inducing hepatic mycrosomal enzymes, inhibiting 25-hydroxilation of vitamin D. They also inhibit intestinal calcium transport and bone mineral mobilization, independent of effects on vitamin D metabolism. This paper presents a patient who was unable to walk due to anticonvulsants induced osteomalacia. Anticonvulsant use has been implicated as a cause of bone disease for more than 30 years but there is no official recommendation for calcium and vitamin D therapy in anticonvulsant treated individuals.

Ključne riječi

anticonvulsants; side-effect; osteomalacia

Hrčak ID:

125315

URI

https://hrcak.srce.hr/125315

Datum izdavanja:

1.7.2008.

Podaci na drugim jezicima: hrvatski

Posjeta: 919 *