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Reumatizam, Vol. 52 No. 1, 2005.

Izvorni znanstveni članak

DRB1 gens distribution in Croatian arthritis patients

Nadica Laktašić-Žerjavić ; Klinika za reumatske bolesti i rehabilitaciju, Klinički bolnički centar Zagreb, Zagreb, Hrvatska
Dragica Soldo-Jureša ; Zavod za kliničku imunologiju i reumatologiju, Klinika za unutarnje bolesti, Klinička bolnica “Dubrava”, Zagreb, Hrvatska
Đurđica Babić-Naglić ; Klinika za reumatske bolesti i rehabilitaciju, Klinički bolnički centar Zagreb, Zagreb, Hrvatska
Božidar Ćurković ; Klinika za reumatske bolesti i rehabilitaciju, Klinički bolnički centar Zagreb, Zagreb, Hrvatska
Kristina Potočki ; Klinički zavod za dijagnostičku i intervencijsku radiologiju, Klinički bolnički centar Zagreb, Zagreb, Hrvatska
Renata Žunec ; Zavod za tipizaciju tkiva, Klinika za urologiju, Klinički bolnički centar Zagreb, Zagreb, Hrvatska
Goran Ivanišević ; Klinika za reumatske bolesti i rehabilitaciju, Klinički bolnički centar Zagreb, Zagreb, Hrvatska

Puni tekst: hrvatski pdf 438 Kb

str. 12-16

preuzimanja: 2.910

citiraj

Sažetak

Genetic association between particular HLA-DRB1 genes and severity of rheumatoid arthritis (RA) has been documented in various clinical investigations. Susceptible alleles are *0401, *0404, *0405, *0408, *0101, *1001, *1402. According to the Shared epitope hypothesis presence of these alleles were considered as poor prognostic sign. The aim was to investigate HLA-DRB1 distribution in Croatian arthritis patients. Group of 90 patients with non-specific joint arthritis, non-erosive RA and erosive RA were typed for DRB1 alleles by PCR-SSP method. Susceptible alleles were identified in 58 (64.44 %) patients. The most frequent genes were DRB1 *0101 (43.33 %), *0401 (17.77 %), *0404 (10 %). 9 out of 58 DRB1* positive patients had 2 susceptible alleles, and the rest (49 patients) had only one susceptible allele. The patients with non-specific joint arthritis and non-erosive RA will bee closely followed for more destructive disease course in DRB1* positive patients.

Ključne riječi

rheumatoid arthritis; shared epitope; HLA-DRB1 alleles

Hrčak ID:

125958

URI

https://hrcak.srce.hr/125958

Datum izdavanja:

1.7.2005.

Podaci na drugim jezicima: hrvatski

Posjeta: 12.093 *