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A Fast Method for DEFB1-44C/G SNP Genotyping in Brazilian Patients with Periodontitis

Renata Cimões orcid id ; Federalno sveučilište Pernambuco, Recife, Brazil
Rafael Rafael Amorim Cavalcanti de Siqueira ; Federalno sveučilište Pernambuco, Recife, Brazil
Sergio Crovella ; Federalno sveučilište Pernambuco, Recife, Brazil
Paulo Roberto Eleutério de Souza ; Federalno sveučilište Pernambuco, Recife, Brazil
Nikos Donos ; Zavod za parodontologiju Eastmanova stomatološkog instituta, London, Ujedinjeno Kraljevstvo

Puni tekst: hrvatski pdf 279 Kb

str. 208-215

preuzimanja: 404


Puni tekst: engleski pdf 279 Kb

str. 208-215

preuzimanja: 449



Aim: Defensins are cationic antimicrobial peptides expressed in epithelial cells. Such peptides exhibit antibacterial, antifungal and antiviral properties, and are a component of the innate immune response. It has been suggested that they have a protective role in the oral cavity. This study evaluated the DEFB1 polymorphism in diabetic patients with or without periodontitis in comparison to healthy controls. Material and Methods: We used Hairpin-Shaped Primer (HP) assay to study the distribution of the -44 C/G SNP (rs1800972) in 119 human DNAs obtained from diabetic patients and healthy control patients. Results: The results indicate that there are no differences in
distribution between groups and that in diabetic periodontitis patients the homozygous mutant could be found more frequently. Conclusion: Further studies are necessary in order to investigate the role of DEFB1 polymorphisms in diabetic periodontitis patients and the influence of the peptide in periodontal pathogens.

Ključne riječi

Defensins, Antimicrobial Cationic Peptides, DEFB1 protein, human, Epithelial Cells, Diabetes Complications, Periodontitis

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Podaci na drugim jezicima: hrvatski

Posjeta: 1.316 *