Pregledni rad
https://doi.org/10.15255/KUI.2014.019
1,3-Dipolar Cycloaddition (Part II): Three-Component Cu(I) Catalysed Click Reactions
L. Krstulović
; Zavod za kemiju i biokemiju, Veterinarski fakultet, Sveučilište u Zagrebu Heinzelova 55, 10 000 Zagreb, Hrvatska
D. Saftić
; Laboratorij za supramolekularnu i nukleozidnu kemiju, Zavod za organsku kemiju i biokemiju, Institut Ruđer Bošković, Bijenička cesta 54, 10 000 Zagreb
J. Matić
; Laboratorij za studij interakcija biomakromolekula, Zavod za organsku kemiju i biokemiju,Institut Ruđer Bošković, Bijenička cesta 54, 10 000 Zagreb
M. Bajić
; Zavod za kemiju i biokemiju, Veterinarski fakultet, Sveučilište u Zagrebu Heinzelova 55, 10 000 Zagreb, Hrvatska
B. Žinić
; Laboratorij za supramolekularnu i nukleozidnu kemiju, Zavod za organsku kemiju i biokemiju, Institut Ruđer Bošković, Bijenička cesta 54, 10 000 Zagreb
Sažetak
The Cu(I) catalysed reaction of sulfonyl or phosphoryl azide and terminal alkyne obtains a ketenimine intermediate that reacts with nucleophiles like water, alcohols, amines, imines, pyrroles or indoles producing corresponding amides, imidates, amidines and substituted heterocycles, in one reaction step. These selective reactions are characterised by mild reaction conditions (room temperature, presence of air and water), without steric or electron influence of substituents on the reaction outcome.
Ključne riječi
Alkyne; azide; click chemistry; copper; three-component reaction
Hrčak ID:
145124
URI
Datum izdavanja:
17.9.2015.
Posjeta: 2.113 *