Stručni rad

Contemporary treatment of hypertension by fixed-dose combination of telmisartan- hydrochlorothiazide

Goran Krstačić orcid.org/0000-0003-0427-7229 ; Poliklinika za prevenciju kardiovaskularnih bolesti i rehabilitaciju, Zagreb, Hrvatska

Sažetak

Fixed-dose combination of telmisartan and hydrochlorothiazide is another contemporary option of effective treatment of hypertension. It is a combination of an angiotensin II receptor blocker, telmisartan and thiazide diuretic, hydrochlorothiazide. Telmisartan reduces cardiovascular risk not only by reducing blood pressure (BP), but also by reducing other metabolic parameters that have a positive effect on cardiovascular diseases, especially selective modulation of PPAR-γ. Hydrochlorothiazide has an effect on the renal tubular mechanisms of electrolyte reabsorption, directly increasing excretion of sodium and chloride in approximately equal amounts. Different combinations of telmisartan and hydrochlorothiazide (40/12.5; 80/12.5 and 80/25mg) are used in the treatment of hypertension in adults whose BP is not well controlled by using telmisartan alone or in patients who have been previously stabilized by telmisartan and hydrochlorothiazide administered separately.

Ključne riječi

telmisartan; hydrochlorothiazide; hypertension; blood pressure; cardiovascular risk

Hrčak ID:

146876

URI

https://hrcak.srce.hr/146876

Datum izdavanja:

26.3.2014.

Podaci na drugim jezicima: hrvatski

Posjeta: 1.771 *