Acta clinica Croatica, Vol. 41 No. 2, 2002.
Izlaganje sa skupa
Effect of Morphologic Cell Types on the Expression of bcl-2, Ki-67 and P-53 in Uveal Melanomas
A. Krvavica
J. Talan-Hranilović
M. Belicza
Sažetak
Uveal melanomas are known to be less aggressive malignant tumors compared with melanoma of other localizations but the same morphological characteristics. We hypothesized that immunohistochemical determination of expression of the known proliferation markers bcl-2 and ki-67, and p-53 as a suppressor gene marker, could better explain the biological behavior of uveal melanoma vs. melanoma of other localizations. Thirty cases of primary uveal melanoma of two levels of invasion were tested retrospectively for the presence of bcl-2, Ki-67 and p-53 proteins with the indirect peroxidase-antiperoxidase immunoenzyme method and three step ABC/AP method. The intensity of reaction was assessed by semiquantiative method.
Ključne riječi
Bcl-2 oncoprotein; Ki-67 oncogene; p-53 supressor gene; uveal melanoma
Hrčak ID:
15208
URI
Datum izdavanja:
3.6.2002.
Posjeta: 1.389 *