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The mechanism of chronotropic activity of caffeine and theophylline in guinea pigs

D. Atanacković ; Farmakološki institut Medicinskog fakulteta, Rijeka
A. Simonić ; Farmakološki institut Medicinskog fakulteta, Rijeka
A. Frković ; Farmakološki institut Medicinskog fakulteta, Rijeka


Puni tekst: hrvatski pdf 6.980 Kb

str. 165-174

preuzimanja: 664

citiraj


Sažetak

The chronotropic activity of caffeine and theophylline on the isolated right atrium of the guinea pig was examinated. Theophylline caused a significant and caffeine only a slight increase in the atrial rate. Reserpine and alpha methyl DOPA diminished the chronotropic activity of the Investigated methyl xanthines. Propranolol caused a decrease in the atrial rate. Caffeine and theophylline potentiated the negative chronotropic activity of propranolol.

Ključne riječi

Hrčak ID:

160050

URI

https://hrcak.srce.hr/160050

Datum izdavanja:

14.10.1980.

Podaci na drugim jezicima: hrvatski

Posjeta: 1.791 *