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The role of cytology in preoperative assessment od primary fallopian tube carcinoma: case report

Roberta Rubeša-Mihaljević ; Zavod za kliničku citologiju, KBC Rijeka, Rijeka
Damjana Verša Ostojić ; Zavod za kliničku citologiju, KBC Rijeka, Rijeka
Morana Dinter ; Zavod za kliničku citologiju, KBC Rijeka, Rijeka
Snježana Štemberger-Papić ; Zavod za kliničku citologiju, KBC Rijeka, Rijeka
Senija Eminović ; Zavod za patologiju i patološku anatomiju, Medicinski fakultet Sveučilišta u Rijeci, Rijeka
Ines Krištofić ; Klinika za ginekologiju i porodništvo, KBC Rijeka, Rijeka
Danijela Vrdoljak-Mozetič ; Zavod za kliničku citologiju, KBC Rijeka, Rijeka

Puni tekst: hrvatski pdf 1.200 Kb

str. 415-420

preuzimanja: 2.397



Aim: To report a case of a patient with primary serous carcinoma of the fallopian tube, describe the diagnostic pathway and analyze the role of cytology in the detection of this tumor type. Case report: A 50-year-old patient was previously treated in another hospital for abdominal pain and radiologically confirmed enlargement of supraclavicular, aortocaval and iliac lymph nodes. A lymphoproliferative disorder was suspected and laparoscopic lymph node excision was performed. Histopathological and immunohistochemical analysis revealed a metastatic adenocarcinoma probably of gynecologic or breast cancer origin. Radiographic examination of the breast did not confirm any lesion suspicious for malignancy. Positron emission tomography/computed tomography observed increased radiotracer uptake involving the uterine cervix and corpus. Preoperative fine-needle aspiration cytology and immunocytochemical analysis of an enlarged supraclavicular lymph node was done and metastatic serous adenocarcinoma was confirmed. In the Pap smears malignant cells of equal morphology were found without tumor diathesis indicating an extra-uterine adenocarcinoma. It was suggested to consider a tumor of ovarian or fallopian tube origin. A total hysterectomy with bilateral salpingo-oophorectomy was performed. During surgery an enlargement of the was observed due to tumor growth extending through the tubal wall. The presence of malignant adenocarcinoma cells was found in the peritoneal washing. Histopathological analysis confirmed a primary serous carcinoma of the fallopian tubes with metastatic spread to the ovaries. Conclusion: Applying fast and precise cytology and immunocytochemistry techniques a correct diagnostic and therapeutic approach can be performed and implemented on time. The present case confirms that cytology is a wellestablished and widely accepted method for diagnosing tumors with unusual clinical presentation or unknown origin.

Ključne riječi

cytology; diagnosis; fallopian tube carcinoma; immunocytochemistry

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Podaci na drugim jezicima: hrvatski

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