Izvorni znanstveni članak
Comparison of Stent Graft, Sirolimus Stent, and Bare Metal Stent Implanted in Patients with Acute Coronary Syndrome: Clinical and Angiographic Follow-up
Maja Strozzi
Darko Anić
Sažetak
Aim To compare polytetrafluoroethylene stent graft (PTFE) with sirolimus and bare metal stents in reducing in-stent restenosis in native coronary vessels in patients with acute coronary syndrome.
Methods The study included patients who underwent stent implantation in acute coronary syndrome from January 2003 to May 2004. The patients (n = 119) were randomized either to stent graft group (n = 40), sirolimus eluting stent group (n = 39), or bare metal stent group (n = 40). The main outcome measure of the study was the incidence restenosis at 6-month. The secondary outcome was 6-month major adverse coronary event rate. Results The incidence of 6-month major adverse coronary events was similar in all three groups (8 events in stent graft, 9 in sirolimus eluting stent, and 16 in bare metal stent group events). The target lesion revascularization was higher in the bare metal stent group (P = 0.044). Restenosis rate, at six-month follow-up was higher in the bare metal stent group compared with the stent graft and sirolimus eluting stent groups. The percent diameter stenosis in the follow-up was significantly higher in the bare metal stent group (P = 0.005). The late loss was significantly
lower in the sirolimus eluting stent group (mean ± standard eviation, 0.2 ± 0.5 mm), compared with the bare metal stent group (0.7 ± 0.7 mm, P = 0.034). There was a trend of lower late loss in the stent graft group than in the bare metal stent group. Conclusion Three groups of stents implanted in patients with acute coronary syndrome did not differ in the incidence of major adverse cardiac events. Sirolimus-eluting stents had a lower incidence of in-stent restenosis than bare metal stent group. Stent graft implanted in native coronary arteries appears to be safe and efficient in patients with acute oronary syndrome, but a significant reduction in in-stent restenosis
was not achieved.
Ključne riječi
polytetrafluoroethylene stent graft; sirolimus
Hrčak ID:
16445
URI
Datum izdavanja:
20.6.2007.
Posjeta: 1.539 *