Pregledni rad
https://doi.org/10.15255/KUI.2015.050
3-Hydroxypyridin-4-ones (Part I): Preparation and Chelation Ability
Željka Car
orcid.org/0000-0002-7301-6615
; Zavod za organsku kemiju, Kemijski odsjek, Prirodoslovno-matematički fakultet, Sveučilište u Zagrebu, Horvatovac 102A, 10 000 Zagreb
Vesna Petrović Peroković
; Zavod za organsku kemiju, Kemijski odsjek, Prirodoslovno-matematički fakultet, Sveučilište u Zagrebu, Horvatovac 102A, 10 000 Zagreb
Srđanka Tomić Pisarović
; Zavod za organsku kemiju, Kemijski odsjek, Prirodoslovno-matematički fakultet, Sveučilište u Zagrebu, Horvatovac 102A, 10 000 Zagreb
Sažetak
Since the discovery of deferiprone in 1982, so far the only 3-hydroxypyridin-4-one chelator for hard metal ions that is clinically approved, these heterocyclic derivatives have become an intensively studied group of compounds. This review presents the two most common synthetic methods used for the preparation of the heterocyclic 3-hydroxypyridin-4-one structure, the Harris method and the direct procedure, as well as the most important physical and chemical parameters needed for the preliminary evaluation of their chelating abilities.
Ključne riječi
3-hydroxypyridin-4-ones; direct synthesis; Harris method; iron(III); chelating agent; physical and chemical properties
Hrčak ID:
169066
URI
Datum izdavanja:
8.12.2016.
Posjeta: 1.200 *