Liječnički vjesnik, Vol. 133 No. 11-12, 2011.
Izvorni znanstveni članak
TREATMENT OF LANGERHANS CELL HISTIOCYTOSIS IN CHILDREN
Ernest Bilić
Katarina Bojanić
Maja Pavlović Pavlović
Josip Konja
Ranka Femenić
Tomislav Đapić
Anko Antabak
Darko Antičević
Slobodna Murat-Sušić
Karmela , Husar
Kristina Potočki
Ljubica Rajić
Sažetak
Langerhans’ cell histiocytosis (LCH) is a disease characterised by pathologic accumulation and proliferation of histiocytes, cells from the monocyte-macrophage system, in various tissues and organs. In this retrospective study we analyzed patients charts treated in the Department of pediatric hematology and oncology at the University Hospital Zagreb with the diagnosis of LCH. Twenty-two children were diagnosed between January 1st 1996 and December 31st 2010, and all were treated with chemotherapy. 19 patients survived (86%) and the remaining 3 (14%), all under the age of 2 with multisystem disease, died. At the time of diagnosis 12 children (55%) presented with single-system disease, the most common were bone lesions in 8 children (36%). All children were treated according to protocols LCH-I and LCH –III. Eight children had mild complications of treatment and the disease itself. Diabetes insipidus remains in 4 children.
Ključne riječi
: Histiocytosis, Langerhans-cell – diagnosis, pathology, drug therapy; Antineoplastic combined chemotherapy protocols – administration and dosage; Eosinophilic granuloma – surgery
Hrčak ID:
171886
URI
Datum izdavanja:
29.12.2011.
Posjeta: 6.331 *