Ostalo
Tumoral calcinosis presenting as a soft tissue mass in a 16 year old patient
Marija Milković Periša
; University Hospital for Tumors, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Sanda Šitić
; University Hospital for Tumors, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Irena Veliki Dalić
; University Hospital for Tumors, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Ljubica Luetić Cavor
; University Hospital for Tumors, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Ilija Guteša
; University Hospital for Tumors, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Sven Seiwerth
; School of Medicine, University of Zagreb, Zagreb, Croatia
Sažetak
Background: Tumoral calcinosis is a rare clinicopathological condition characterized by periarticular tumor-like calcium deposits most commonly found around major joints, especially the hips, shoulders and elbows. Tumoral calcinosis is not primarily a bone-or cartilage-forming lesion, but it can closely simulate osteocartilaginous tumors. These lesions are predominantly seen during the first two decades of life and may be multicentric or bilateral. Laboratory analysis frequently shows high serum phosphate but normal serum calcium levels.
A 16 year old male presented with a huge mass in the left hip which had been growing for a month. MR detected large tumor mass in the left gluteal region with possible infi ltration of m.gluteus maximus. Soft tissue mass was surgically resected, measuring 24 cm in diameter. Histologically, it was composed of multiple large cystic spaces with nodules of amorphous calcifi ed deposits surrounded by multinucleated giant cells and mononuclear infi ltrates. The lesion was poorly
circumscribed with infi ltration into surrounding striated muscle.
Tumoral calcinosis is an uncommon and benign condition that generally occurs as a complication of trauma or renal dialysis, and is rarely seen in familial and sporadic cases. It can occur in a variety of clinical sett ings: primary normophosphatemic, primary hyperphosphatemic and secondary tumoral calcinosis occuring along with disorders that are capable of producing soft tissue calcifi cation. Histologically, tumoral calcinosis is characterized by amorphous calcifi ed deposits in the
background of granulomatous appearance with multinucleated giant cells and other infl ammatory cells. The diff erential diagnosis is broad and includes all tumoral calcinosis-like lesions that lead to abnormal dystrophic or metastatic calcium deposition in soft tissues. Surgical excision is the primary treatment.
Ključne riječi
tumoral calcinosis; radiology; histopathology
Hrčak ID:
184610
URI
Datum izdavanja:
3.7.2017.
Posjeta: 3.595 *