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https://doi.org/10.5599/admet.5.3.423

ADME-Tox profiling of some low molecular weight water soluble chitosan derivatives

Adriana Isvoran orcid id orcid.org/0000-0002-3068-2642 ; Department of Biology-Chemistry and Advanced Environmental Research Laboratories, West University of Timișoara, Timișoara, Romania
Alecu Aurel Ciorsac ; Department of Physical Education and Sport, University Politehnica Timișoara, Timișoara, Romania
Vasile Ostafe ; Department of Biology-Chemistry and Advanced Environmental Research Laboratories, West University of Timișoara, Timișoara, Romania


Puni tekst: engleski pdf 814 Kb

str. 192-200

preuzimanja: 533

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Sažetak

Within this study we use a few computational tools for predicting absorption, distribution, metabolism, excretion and toxicity (ADME-Tox), pharmacokinetics profiles, toxic/adverse effects, carcinogenicity, cardiotoxicity and endocrine disruption of some of low molecular weight water soluble derivatives of chitosan that are used in wound healing. Investigated compounds do not possess drug-like properties, their pharmacokinetics profiles reveal poor gastrointestinal absorption and low skin penetration. Chitosan derivatives cannot pass the blood-brain barrier and they are not able to inhibit the enzymes of the cytochrome P450 that are involved in the metabolism of xenobiotics. They do not reflect carcinogenicity and cardiotoxicity and reveal only a low probability to be endocrine disruptors. The main side effects in humans of the investigated compounds are: weight loss, acidosis, gastrointestinal toxicity, respiratory failure. This information is especially important for professional exposure and accidental contamination with these compounds.

Ključne riječi

Pharmacokinetics; toxic/adverse effects; carcinogenicity; cardiotoxicity; endocrine disruption

Hrčak ID:

186966

URI

https://hrcak.srce.hr/186966

Datum izdavanja:

29.9.2017.

Posjeta: 1.064 *