ANTI-INFECTIVE AND ANTI-TUMOR ACTIVITY OF SOME METAL COMPLEXES (MII-MIV) WITH SCHIFF BASES
; Department of Chemistry, Faculty of Natural Science and Mathematics, University of Tuzla, Tuzla, Bosnia and Herzegovina
Amira Cipurković ; Department of Chemistry, Faculty of Natural Science and Mathematics, University of Tuzla, Tuzla, Bosnia and Herzegovina
Nevzeta Ljubijankić ; Department of Chemistry, Faculty of Natural Science and Mathematics, University of Sarajevo, Sarajevo, Bosnia and Herzegovina
Research and application of metal complexes of ruthenium, platinum, palladium and other d-block elements has been popular in recent time because the complexes of said metals with a wide range of organic ligands shown to be extremely efficient in the treatment of infectious and malignant diseases. In addition to platinum used long time as Cisplatin, Carboplatin and oxaplatin, new generation of anticancer complexes in their structure containe mainly Ru(II) and Ru(III). In the synthesis of anti-infective and anti-tumor drugs, emphasis is indicated on their cytotoxicity. Specifically, the aim is that the new anti-infective and anti-tumor agent does not damage healthy cells and affects only malignant cells or infectious agents.
In this paper we make reference on some recent and significant researches in the field of inorganic synthesis of metal complexes with strong anti-tumor and anti-infective properties. Special emphasis is placed on the Schiff bases as organic ligands which are specially used in the synthesis of such agents.
Posjeta: 721 *