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Biological chips unlock the secrets of genome

Ana Tomašić Paić
Miroslav Poznić
Snježana Jurić
Hrvoje Fulgosi

Sažetak

Recent advances in microarray technology allowed scientists to investigate expression of thousands of genes in a single reaction, thus generating a vast amount of data. Biological chips, based on hybridization methods, enable detection of genes on a genomic scale. Moreover, chips are used to elucidate fundamental life processes such as cellular and signalling pathways and basic aspects of growth and development of organisms. Recently sequenced model plant Arabidopsis thaliana and human genome revealed that a majority of human genes involved directly or indirectly in certain human diseases have their orthologs in vacular plants. Determination of key proteins involved in human health and disease, especially their gene expression patterns and mutations, are becoming rapidly examined and investigated by using biological chips. These technological advances will hopefully uncover the origin of genetic illnesses and likely lead to creation of specific gene therapies.

Ključne riječi

Gene chips; Affymetrix technology; Arabidopsis thaliana; Human diseases

Hrčak ID:

191927

URI

https://hrcak.srce.hr/191927

Datum izdavanja:

1.12.2010.

Podaci na drugim jezicima: hrvatski

Posjeta: 2.654 *