Medicinski vjesnik, Vol. 24 No. (3-4), 1992.
Pregledni rad
ß-lactamases of Moraxellae catarrhalis and susceptibility to antibiotics
Branka Bedenić
Živojin Žagar
Sažetak
M. catarrhalis is gaining increasing interest as respiratory tract pathogen. High percent of clinical isolats rpoduces ß- lactamase which is responsible for resistance to bea-lactam antibiotics, especially to ampicillin and penicillin. M. catarrhalis produces two main types of ß lastamase: BRO-1 and BRO-2. The both are plasmid mediated, hydrolize penicillin at much higher rate the cephalosporins and are biosinthetised constitutively. They are very sensitive to inhibition by clavulanic acid. The B-lactamase producing strains are in, general resistant, to penicillins. The combination of amoxycillin and clavuranic acid represents the first choice antibiotic in the therapy of infections caused by M. catarrhalis. Eritromycin and cephalosporins can be used too.
Ključne riječi
Moraxella catarrhalis; ß-lactamase; penicillins; clavulanic acid
Hrčak ID:
195517
URI
Datum izdavanja:
1.12.1992.
Posjeta: 2.260 *