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A hypothesis of the possible immunological mechanisms behind the chronic gastritis and peptic ulcerations associated with the campylobacter pylori infection

Sven Kurbel
Beatrica Kurbel


Puni tekst: hrvatski pdf 1.361 Kb

str. 21-23

preuzimanja: 162

citiraj

Puni tekst: engleski pdf 1.361 Kb

str. 21-23

preuzimanja: 84

citiraj


Sažetak

A short review of the data regarding the presence of Campylobacter pylori in the peptic ulcer patients and those with chronic gastritis has been presented together with the data regarding the presence and functions of the gastric mucosal mast cells and IgE molecules at their surface. A speculation is made that the physiological role of the IgE/mast cell system in the gastric mucosa, beside bringing the immunocompetent cells to the place of infection, consists also in producing a local tide in the gastric acid secretion that would facilitate pathogen elimination. Chronic infection with C. pylori and other pathogens could lead to the permanent activation of this system resulting in the chronic gastritis or spots of hyperacidity that might turn into ulcers. Findings of the humoral response to C. pylori in ulcer patients support the presented hypothesis. Further studies of the total and specific IgE content in the gastric mucosa of ulcer patients and experimental animals are required to test its validity.

Ključne riječi

Campylobacter pylori; gastritis; IgE; infection; peptic ulcer

Hrčak ID:

196766

URI

https://hrcak.srce.hr/196766

Datum izdavanja:

1.12.1989.

Podaci na drugim jezicima: hrvatski

Posjeta: 626 *