Pregledni rad
Camparison of FIT to gFOBT in colorectal cancer screening
Mayer Ljiljana
; Clinical Institute of Chemistry, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Mihaela Gaće
; Clinical Institute of Chemistry, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Sanja Dobrijević
; Clinical Institute of Chemistry, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Zvjezdana Špacir-Prskalo
; Clinical Institute of Chemistry, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Sažetak
Most countries provide national screening programs for early detection and prevention of colorectal cancer (CRC). As a result, the incidence and mortality are becoming slightly divergent. Croatian colorectal cancer screening program has begun in 2007 with overall response rate about 20%. This response rate, may be explained by complexity of fecal occult blood test (FOBT) and availability of colonoscopy for positive results.
Recently, European countries started replacing FOBT test in national screening programs with fecal immunochemical test (FIT), which is based on immunochemical method performed by automatic analyzer using the specially designed highly specific antibodies that could detect human hemoglobin exclusively. The main advantages of FIT are higher sensitivity for detection of cancer and higher proportion of true negative.
The aim of the national screening program is to detect the disease as early as possible when CRC is curable. Providing
information on colorectal cancer to general public, along with current national plan and through the application of current guidelines it is possible to increase response rate, early detection, improve quality of life and increase overall survival. In this paper we discuss a possibility of replacing FOBT with FIT attributing to these goals.
Ključne riječi
fecal occult blood test (FOBT); Fecal immunochemical test (FIT); colorectal cancer; screening
Hrčak ID:
200324
URI
Datum izdavanja:
27.12.2013.
Posjeta: 1.767 *