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Pregledni rad

https://doi.org/10.5599/admet.530

The role and impact of high throughput biomimetic measurements in drug discovery

Shenaz Bunally ; Drug Design & Selection, GlaxoSmithKline Medicines Research Centre, Stevenage, SG1 2NY, UK
Robert J. Young orcid id orcid.org/0000-0002-7763-0575 ; Drug Design & Selection, GlaxoSmithKline Medicines Research Centre, Stevenage, SG1 2NY, UK


Puni tekst: engleski pdf 1.227 Kb

str. 74-84

preuzimanja: 676

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Sažetak

During the early phase of drug discovery, it is becoming increasingly important to acquire the full physicochemical profile of molecules. For this purpose, there is a strong interest in developing efficient and cost-effective platforms for fast and reliable measurements of physicochemical properties. We have developed an automated physchem platform which ensures that consistent, comprehensive, and high-quality physicochemical property measurements and derived property information for 100's of compounds per week are available alongside potency data at the right time to guide compound progression decisions. We discuss the routine assessments of biomimetic properties using high throughput automated high-performance liquid chromatography (HPLC) platforms, with details of the methods and hardware employed, also with illustrations of the quality and impact of the data generated.

Ključne riječi

Lipophilicity; Physicochemical properties; Biomimetic Chromatography, Drug Efficiency; Candidate Quality

Hrčak ID:

201566

URI

https://hrcak.srce.hr/201566

Datum izdavanja:

16.6.2018.

Posjeta: 1.280 *