Medica Jadertina, Vol. 48 No. 3, 2018.
Izvorni znanstveni članak
Early discovery of esophagus adenocarcinoma in Barret's mucosa
Melanija Ražov Radas
; Opća bolnica Zadar, Služba za internu medicinu, Odjel za gastroenterologiju
Nataša Šikić Lisica
orcid.org/0000-0003-3371-1151
; Opća bolnica Zadar, Odjel za patologiju i sudsku mkedicinu
Sažetak
The aim of this study was to evaluate the expression of Mucin 2 glycoprotein (MUC2) and Vascular Endothelial Growth Factor (VEGF) in Barrett’s mucosa in association with higher risk for the development of adenocarcinoma (AC). The study included a group of 36 patients with diagnosis of Barrettʹs esophagus (BE) after esophagogastroduodenoscopy, but the pathohistological analysis of esophagogastric junction (EGJ) mucosa showed adenocarcinoma in four patients. The expression of MUC2 and VEGF was performed with immunohistochemistry. MUC2 was expressed in three patients, and VEGF expression was present at three patients in the study, which suggested that angiogenesis could have an important role in replacing normal esophageal mucosa with Barrett’s mucosa.
Ključne riječi
Barrett's esophagus; adenocarcinoma; immunohistochemistry of MUC 2 and VEGF
Hrčak ID:
204588
URI
Datum izdavanja:
20.8.2018.
Posjeta: 2.367 *