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Synthetic Studies in the Chloramphenicol Series. VI. Synthesis of DL - threo-1-p-nitrophenyl-1 -hydroxy-2-dichloroacetamido-3- methylsulfinyl and 3-methylsulfonyl propane

M. Fleš ; Research Department, »Pliva« Pharmaceutical and Chemical Works, Zagreb, Croatia, Yugoslavia


Puni tekst: engleski pdf 7.542 Kb

str. 257-262

preuzimanja: 286

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Sažetak

The compounds mentioned in the title were prepared from
a.-phthalimido-~-methylmercaptopropiophenone (I). Reduction of
I with aluminium isopropoxide gave preferentially the threo carbinol
II which upon acetylation and subsequent nitration gave
a mixture of diastereomeric sulfoxides which were oxidized with
hydrogen peroxide to the identical sulfones.

Ključne riječi

Hrčak ID:

208323

URI

https://hrcak.srce.hr/208323

Datum izdavanja:

28.2.1964.

Posjeta: 745 *