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Synthesis of 2-iso-Propyl-3-methyl-huten-(3)-ol-(l)

K Šestanj ; Research Department »Pliva« Pharmaceutical and Chemical Works, Zagreb, Croatia, Yugoslavia


Puni tekst: engleski pdf 6.202 Kb

str. 127-131

preuzimanja: 106

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Sažetak

The title compound was synthesized in the following way:
Reforinatsky condensation ·of ethyl a -bromo-iso-valerate with
acetone and zinc to ethyl 3-hydroxy-2-iso-propyl-3-methyl-butyrate
(1), dehydration to the mixture of ethyl 2-iso-propyl-3-methylbuten-(
3)-oate (II) and 2-iso-propyl-3-methyl-buten-(2)-oate (IV),
and lithium aluminum hydride reduction to 2-iso-propyl-3-methylbuten-(
3)-ol-(1) (VI). The mixture of esters was hydrolysed to
2-iso-propyl-3-methyl-buten-(3)-oic acid (III) which gave on
reduction with lithium aluminum hydride the same alcohol VI.
Proof of the structure of the acid III was accomplished by means
of chemical and physical methods.

Ključne riječi

Hrčak ID:

208433

URI

https://hrcak.srce.hr/208433

Posjeta: 218 *