Ostalo

https://doi.org/10.15836/ccar2019.194

The Importance of the Smoothness Index in Managing Hypertension

Rok Accetto ; Združenje za hipertenzijo, Slovensko zdravniško društvo, Ljubljana, Slovenija

Sažetak

Average clinic blood pressure (BP) is the gold standard for the diagnosis and treatment of hypertension. However, BP fluctuates throughout the day and the measurement does not always reflect the actual BP. Therefore it is also important to measure BP variability, which has been associated with an increased frequency of cardiovascular events, death, and target organ damage. Treatment has to be directed not only towards reducing the 24-hour BP average but also towards normalizing
the variability of BP during the day and at night. It has been found that reduction in average BP leads to a proportional reduction in its variability, which is why the use of long-acting medications may
be beneficial in controlling hypertension. A 24-hour BP reading offers several advantages, such as providing information on the maximum effect and duration of effect of hypertension medication and
enabling calculation of the smoothness index. A meta-analysis of studies demonstrated different effects and smoothness indices among hypertension medications. The smoothness index was higher
for combined medications and medications at higher doses. Medications with a higher smoothness index have been shown to be superior in providing cardiovascular protection and preventing target
organ damage.

Ključne riječi

blood pressure variability; 24-hour blood pressure measurement; smoothness index; cardiovascular protection.

Hrčak ID:

226614

URI

https://hrcak.srce.hr/226614

Datum izdavanja:

17.9.2019.

Podaci na drugim jezicima: hrvatski

Posjeta: 1.938 *