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Pregledni rad

https://doi.org/10.5599/admet.737

NMR spectroscopy in drug discovery and development: Evaluation of physico-chemical properties

Mire Zloh orcid id orcid.org/0000-0002-4848-2737 ; UCL School of Pharmacy, University College London, 29/39 Brunswick Square, London, WC1N 1AX, UK


Puni tekst: engleski pdf 752 Kb

str. 242-251

preuzimanja: 720

citiraj


Sažetak

Determination of physico-chemical properties of compounds is one of the corner-stones in selection of hit molecules for further progression into lead development in the modern drug discovery process. The speed of traditional analyses and limited quantities of hit molecules are obstacles for efficient acquisition of experimental data. Herein, the range of applications of quantitative nuclear magnetic resonance (NMR) spectroscopy as a fast technique used to evaluate solubility, log P and pKa are discussed.

Ključne riječi

logP; qNMR; drug solubility; DOSY; pharmaceutical formulations.

Hrčak ID:

229487

URI

https://hrcak.srce.hr/229487

Datum izdavanja:

11.12.2019.

Posjeta: 1.216 *