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Vascular Health and Cardiovascular Outcomes: Focus on Perindopril and its Combinations

Tina Kuhar ; Krka, d. d., Novo mesto, Slovenija
Alenka Kmecl ; Krka, d. d., Novo mesto, Slovenija
Mateja Grošelj ; Krka, d. d., Novo mesto, Slovenija
Breda Barbič-Žagar orcid id ; Krka, d. d., Novo mesto, Slovenija

Puni tekst: hrvatski pdf 277 Kb

str. 229-235

preuzimanja: 239


Puni tekst: engleski pdf 277 Kb

str. 229-235

preuzimanja: 771



Endothelial dysfunction is the earliest vascular abnormality and it is involved in all stage of the cardiovascular continuum. Antihypertensive compounds should ideally have additional endothelial protective properties beyond their ability to reduce blood pressure. Among angiotensinconverting enzyme inhibitors, perindopril appears to have the greatest endothelial protective effects. Amlodipine is well known for its atheroprotective effect. Clinical evidence has shown that perindopril and amlodipine could individually interrupt and slow the progression of cardiovascular disease with long-term beneficial effects of treatment on mortality. The effect is enhanced and broadened if both agents are used together. Early prescription of perindopril and amlodipine appears to be important, as most of the treatment benefits of both agents occur in the early or middle stages of the cardiovascular continuum. Clinical evidence also supports the beneficial effect on the vascular endothelium offered by the triple combination of perindopril and amlodipine with indapamide.

Ključne riječi

perindopril; amlodipine; endothelial dysfunction; cardiovascular continuum

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Podaci na drugim jezicima: hrvatski

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