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https://doi.org/10.15255/KUI.2020.025

Redox Properties of Ferrocene-substituted Nucleobases

Mateja Toma orcid.org/0000-0002-7535-1345 ; Sveučilište u Zagrebu Farmaceutsko-biokemijski fakultet, Ante Kovačića 1, 10 000 Zagreb
Valerije Vrček orcid.org/0000-0003-1624-8126 ; Sveučilište u Zagrebu Farmaceutsko-biokemijski fakultet, Ante Kovačića 1, 10 000 Zagreb

Sažetak

A series of ferrocene-substituted purine-nucleobase derivatives 1-10 were synthesized and their redox potential was measured by cyclic voltammetry. Measured compounds showed a reversible one-electron oxidation in the range of 330–470 mV. A difference of 100 mV between N7 and N9 regioisomers was observed. In order to examine the tendency of ferrocene-nucleobase conjugates to produce reactive oxygen species (ROS), an acellular screening with DCFH₂-DA assay was carried out. The nucleobases coupled with ferrocene generated ROS, while neither ferrocene itself nor the nucleobases were active. Changing the substituents on the purine ring can significantly influence the ROS generation of ferrocene-substituted nucleobases, which support design of biologically active ferrocene-nucleobase conjugates.




This work is licensed under a Creative Commons Attribution 4.0 International License.

Ključne riječi

ferrocene-substituted purine-nucleobase; redox potential; reactive oxygen species (ROS)

Hrčak ID:

247622

URI

https://hrcak.srce.hr/247622

Datum izdavanja:

14.12.2020.

Podaci na drugim jezicima: hrvatski

Posjeta: 1.166 *