Sažetak sa skupa
The Effect of Chlorhexidine on Oral Bacterial Colonisation and Development of Nosocomial Infections in Life Threatened Patients
Tomislav Ćabov
Darko Macan
Ino Husedžinović
Danica Bošnjak
Jasenka Škrlin-Šubić
Sažetak
Aims: To record the effect of decontamination of dental plaque and buccal mucous membrane by antiseptics on the colonisation of potential pathogenic nosocomial bacteria and development of nosocomial infections in patients in the Department of Intensive Care.
Type: A double blind prospective comparative study based on a randomly selected sample.
Location: Department of Intensive Care with 12 beds in the University Hospital Dubrava.
Subjects: Patients admitted one after the other in the Department of Intensive Care with a disease which indicated at least three days of treatment. Edentulous patients were excluded from the study.
Therapy: After randomly selecting the patients, the group was treated with 0.2% gel chlorhexidine, three times daily for the duration of their stay in the Department. Standard measures of oral hygiene and placebo gel were applied in a control group.
Specific measurements: Dental status was taken by means of caries index; the amount of plaque was determined by means of semi quantitative plaque index. Samples of bacteria were taken of dental plaque, buccal mucous membrane, nasal and tracheal aspirate and blood on the first, third and sixth day and thereafter every three days until the patient's release from the Department of Intensive Treatment.
Results: Sixty patients participated in the study: 30 who received therapy and 30 in a control group (mean age: 54.5±5.5 years, Simplified Acute Physiological Score II: 29±13.5 points). On admittance to hospital there were no significant differences between the two groups with regard to clinical and dental data. Average value of the caries index amounted to 19.5±5.5, and plaque index 1.7±0.62. On the day of admittance potentially pathogenic nosocomial bacteria were isolated from the area of dental plaque and buccal mucous membrane in 63% of patients. In relation to the control group the amount of transcolonisation of bacteria in the region of the bronchi was significantly reduced (19/7 patients, p=0.002), as also was the incidence of the development of nosocomial infections (26.7%/6.7%, p=0.041). These results were consistent with the significant preventive effect of antiseptic decontamination with 75% relatively reduced risk. There was a trend toward a decrease in the values of plaque index, colonisation of potential pathogenic bacteria and the duration of stay in the Department of Intensive Care.
Conclusions: Decontamination of dental plaque and buccal mucous membrane by antiseptics, 0.2% gel chlorhexidine, reduced oral bacterial colonisation, and can reduce the incidence of the development of nosocomial infections in life threatened patients.
Ključne riječi
colonisation of the oropharyngeal region; nosocomial infections; decontamination by antiseptics; chlorhexidine
Hrčak ID:
2299
URI
Datum izdavanja:
15.12.2004.
Posjeta: 1.812 *