Izvorni znanstveni članak
https://doi.org/10.20471/acc.2021.60.s1.04
Determining The Factors that Influence Blood Pressure Variability in Children with Essential Hypertension
Iva Škorić
orcid.org/0000-0002-0710-3243
; Department of Pediatrics, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia
Matej Šapina
orcid.org/0000-0002-4376-708X
; University Hospital Osijek, Osijek, Croatia; Faculty of Medicine, JJ Strossmayer University of Osijek, Osijek, Croatia; Faculty of Dental Medicine and Health, JJ Strossmayer University of Osijek, Osijek, Croatia
Ivana Trutin
orcid.org/0000-0001-8419-0427
; Department of Pediatrics, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia
Karolina Kramarić
; University Hospital Osijek, Osijek, Croatia; Faculty of Dental Medicine and Health, JJ Strossmayer University of Osijek, Osijek, Croatia
Ivica Škoro
; University Hospital Osijek, Osijek, Croatia
Mario Laganović
; School of Medicine, University of Zagreb, Zagreb, Croatia; University Hospital Centre Zagreb, Zagreb, Croatia
Sažetak
This study aimed to analyze blood pressure (BP) patterns, assess blood pressure
variability (BPV), and its possible determinants in children with essential hypertension. The study
group included 132 children with essential hypertension without antihypertensive therapy. Anthropometric
and laboratory parameters were evaluated, office and ambulatory BP were measured. BPV was
defined as the standard deviation of BP for the day and nighttime periods. In addition to classical
statistical analysis, an unsupervised machine learning approach using the expected maximization algorithm
was implemented to find groups of patients with similar characteristics. No differences in
BPV were observed between sexes; however, boys had higher levels of creatinine, serum glucose, and
uric acid despite similar body mass index values. There was a significant correlation between the Zscore
for body mass index and daytime systolic BPV (r=0.19, p<0.05). Nighttime BPV significantly
correlated with total cholesterol and uric acid levels. Within the male population, two clusters were
found. The subjects in Cluster 2 had higher daytime and nighttime systolic and diastolic BP values,
total cholesterol, triglycerides, and nighttime systolic and diastolic BPV. Our results suggest that the
clustering of metabolic factors influences BPV in untreated children with essential hypertension,
which may be a sex-specific effect in males.
Ključne riječi
Blood pressure variability; Hypertension; Ambulatory blood pressure monitoring
Hrčak ID:
260287
URI
Datum izdavanja:
1.1.2021.
Posjeta: 694 *