Izvorni znanstveni članak

https://doi.org/10.20471/acc.2021.60.s1.12

Quantifying Microvascular Abnormalities in Chronic Kidney Patients

Damir Rebić orcid.org/0000-0003-4296-9453 ; Clinic for Nephrology, Clinical Center University of Sarajevo, Bosnia and Herzegovina, Bosnia and Herzegovina; Faculty of Medicine, University of Sarajevo, Bosnia and Herzegovina
Aida Hamzić-Mehmedbašić ; Clinic for Nephrology, Clinical Center University of Sarajevo, Bosnia and Herzegovina, Bosnia and Herzegovina; Sarajevo Medical School, University Sarajevo School of Science and Technology, Bosnia and Herzegovina
Orhan Lepara ; Faculty of Medicine, University of Sarajevo, Bosnia and Herzegovina
Azra Ribić-Mrkonja ; Clinic for Nephrology, Clinical Center University of Sarajevo, Bosnia and Herzegovina, Bosnia and Herzegovina
Zahid Lepara ; Clinic for Nephrology, Clinical Center University of Sarajevo, Bosnia and Herzegovina, Bosnia and Herzegovina; Clinic for Urology, Clinical Center University of Sarajevo, Bosnia and Herzegovina
Senad Hasanspahić ; Clinic for Nephrology, Clinical Center University of Sarajevo, Bosnia and Herzegovina, Bosnia and Herzegovina

Sažetak

Introduction. Ocular microvascular changes can be related to kidney deterioration
in chronic kidney disease (CKD). We aimed to identify the association between retino-choroidal
parameters and kidney deterioration in diabetics and non-diabetics.
Methods. The study group consisted of CKD patients (cross-sectional study) with arterial
hypertension
with different stages of CKD. Complete eye examination was completed with optical
coherence tomography angiography (OCTA) scans of the macular region. According to the value of
glomerular filtration rate (GFR) and albuminuria, patients were divided into groups: low GFR
(<60ml/min) and high GFR (>60ml/min) and CKD patients without albuminuria and CKD with
micro or macroalbuminuria.
Results. One hundred and six eyes of 106 chronic kidney disease patients were evaluated. The mean
retinal thickness in GFR <60 ml/min group was 275,73±9,65 micron (μ), whereas in a GFR >60 ml/min
group was 274,36±10,77 μ. OCTA showed lower deep vascular density (DVD ) in CKD with albuminuria
versus CKD without albuminuria group (p < 0.001). Albuminuria was inversely related to
choroidal and retinal thickness measures of superficial (SVD) and DVD .
Conclusions. CKD is associated with retinal diluting and decreasing kidney function with reduction
of retinal and choroidal vascular density.

Ključne riječi

Microvasculature; Chronic kidney disease; OCTA; Chorioretinal thickness; Vascular density

Hrčak ID:

260406

URI

https://hrcak.srce.hr/260406

Datum izdavanja:

1.1.2021.

Podaci na drugim jezicima: hrvatski

Posjeta: 688 *