Izvorni znanstveni članak
https://doi.org/10.15255/KUI.2021.035
Comparative Therapeutic Properties of Garlic Extract and Metformin on Hyperglycaemia, Hypercholesterolaemia, and Hypertriglyceridaemia in Alloxan-induced Type1-like Diabetic Rats
Djamel Atsamnia
; Biomaterials and Transport Phenomena Laboratory (LBMPT), Dr Yahia Fares University of Médéa, Alžir
Salah Hanini
; Biomaterials and Transport Phenomena Laboratory (LBMPT), Dr Yahia Fares University of Médéa, Alžir
Dahmane Oukrif
orcid.org/0000-0001-8645-158X
; University College London, Department of Pathology, Ujedinjeno Kraljevstvo
Karine Benachour
; Laboratory of Experimental Biology and Pharmacology, Faculty of Sciences, Dr Yahia Fares University of Médéa, Alžir
Othmane Benkortbi
orcid.org/0000-0002-1965-7171
; Biomaterials and Transport Phenomena Laboratory (LBMPT), Dr Yahia Fares University of Médéa, Alžir
Mabrouk Hamadache
; Biomaterials and Transport Phenomena Laboratory (LBMPT), Dr Yahia Fares University of Médéa, Alžir
Sažetak
The current pilot study was conducted to compare the triple effect of garlic extract and metformin on hyperglycaemia, hypercholesterolaemia, and hypertriglyceridaemia in alloxan-induced type 1-like diabetic rats. Wistar rats were randomly divided into four groups. Control group included normal rats. The second group included alloxan-induced type 1-like diabetic rats, receiving no treatment. The other two groups of diabetic rats were orally treated with 0.75 g of garlic extract per kg of body weight and 0.05 of metformin g per kg of body weight respectively for four weeks. The pharmacological impact of garlic compounds on serum glucose and lipids as opposed to the glucose-lowering and lipid-lowering was highlighted in these experiments. These results revealed that garlic extract has a triple action on hyperglycaemia, hypertriglyceridemia, and hypercholesterolemia. Its effect on hyperglycaemia is long lasting, and more pronounced compared to the metformin. Interestingly, it had a regulatory effect on glycaemia as highlighted in the control group.
This work is licensed under a Creative Commons Attribution 4.0 International License.
Ključne riječi
alloxan; diabetes; garlic extract; glycaemia; metformin
Hrčak ID:
274065
URI
Datum izdavanja:
16.3.2022.
Posjeta: 735 *