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Acta Pharmaceutica, Vol. 72 No. 4, 2022.

Kratko priopćenje

https://doi.org/10.2478/acph-2022-0036

Anti-inflammatory effects of NaB and NaPc in Acinetobacter baumannii-stimulated THP-1 cells via TLR-2/NF-κB/ROS/NLRP3 pathway

CHEN SHU ; General Surgery Department, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, 215006, China; General Surgery Department, Affiliated Hospital of Jiangsu University, Jiefang Road No. 438, Zhenjiang, Jiangsu, 212000, China
ZHANG YAN-YAN ; Testing Center, Yangzhou University, Wenhui Road No. 48, Yangzhou, Jiangsu, 225009, China
ZHANG HAI ; General Surgery Department, Affiliated Hospital of Jiangsu University, Jiefang Road No. 438, Zhenjiang, Jiangsu, 212000, China
DING LONG-KUN ; School of Medicine, Jiangsu University, Xuefu Road No.301, Zhenjiang, Jiangsu, 212013, China
XI YUE ; School of Medicine, Jiangsu University, Xuefu Road No.301, Zhenjiang, Jiangsu, 212013, China
YAN MAN ; School of Medicine, Jiangsu University, Xuefu Road No.301, Zhenjiang, Jiangsu, 212013, China
SUN CHANG ; School of Medicine, Jiangsu University, Xuefu Road No.301, Zhenjiang, Jiangsu, 212013, China
WU LIANG ; School of Medicine, Jiangsu University, Xuefu Road No.301, Zhenjiang, Jiangsu, 212013, China
HU HAO ; General Surgery Department, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, 215006, China

Puni tekst: engleski pdf 5.016 Kb

str. 615-628

preuzimanja: 302

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Sažetak

This study evaluated the anti-inflammation effect of the three main short-chain fatty acids (SCFAs) on Acinetobacter baumannii-induced THP-1 cells. The three main SCFAs could inhibit A. baumannii-stimulated THP-1 cell NF-κB pathway activity and the expressions of NLRP3 inflammasome and GSDMD, and increase autophagy. The three main SCFAs, especially the sodium butyrate (NaB), had the effect of down-regulation of ROS and TLR-2 expression in THP-1 cells. NaB and sodium propionate (NaPc), but not sodium acetate (NaAc), dramatically suppressed IL-1β and IFN-γ expression. The results indicated that NaB and NaPc could significantly inhibit the inflammation of THP-1 cells induced by A. baumannii, and the inhibitory effect was in the order of NaB＞NaPc＞NaAC. NaB and NaPc may inhibit inflammation through TLR-2/NF-κB/ROS/NLRP3 signaling pathway.

Ključne riječi

short chain fatty acids (SCFAs); autophagy; NLRP3; nuclear factor-κB (NF-κB); inflammation

Hrčak ID:

275630

URI

https://hrcak.srce.hr/275630

Datum izdavanja:

31.12.2022.

Posjeta: 803 *