Izvorni znanstveni članak
Role of heredity in patients with prostate cancer
Davorin Katušin
; Karlovac General Hospital, Department of Urology, Karlovac, Croatia
Miljenko Križ
; Karlovac General Hospital, Department of Urology, Karlovac, Croatia
Željko Poka
; Karlovac General Hospital, Department of Urology, Karlovac, Croatia
Jasminka Sušanj
; Karlovac General Hospital, Department of Urology, Karlovac, Croatia
Doroteja Janković
; Karlovac General Hospital, Department of Urology, Karlovac, Croatia
Sažetak
We distinguish three epidemiological forms of prostate cancer (PCa): 1) sporadic – occurring randomly in the population; 2) familial – unpredictable and weak clustering of PCa in families; and 3) hereditary – strong clustering and early onset of PCa. It was estimated that approximately 10-20% of patients with PCa have a positive family history. Twenty-eight (3.3%) of 827 patients with histopathologically confirmed PCa in our study had a positive family history with one of the first degree relative (father, son or brother) affected by the disease. Median age of the patients with familial PCa was 67.5 years and it was significantly lower than in sporadic cases (median 72.0 years) (p=0.018). We assessed no significant difference between the groups in the pretreatment prostatic specific antigen (PSA) level, Gleason score distribution, median time to progression and overall mortality. Patients with positive family history on PCa had a significantly higher tumor stage at presentation (p<0.01), higher frequency of tumor progression (p=0.013) and higher tumor-specific mortality (p=0.027) during the follow-up.
In conclusion, because of earlier onset and possible more aggressive nature of the familial PCa, positive familial history must be taken into consideration when to start PSA screening and when to indicate prostate biopsy in men with slightly elevated PSA.
Ključne riječi
prostate cancer; familial prostate cancer; hereditary prostate cancer
Hrčak ID:
278480
URI
Datum izdavanja:
21.10.2010.
Posjeta: 342 *