Review article
https://doi.org/10.15255/KUI.2021.072
The Chloroquine Story in the First Year of the COVID-19 Pandemic
Matea Hunić
orcid.org/0000-0001-5680-7063
; Department of Chemistry and Biochemistry, Faculty of Food Technology and Biotechnology, University of Zagreb, Pierottijeva 6, 10 000 Zagreb, Croatia
Renata Teparić
orcid.org/0000-0002-3454-700X
; Department of Chemistry and Biochemistry, Faculty of Food Technology and Biotechnology, University of Zagreb, Pierottijeva 6, 10 000 Zagreb, Croatia
Monika Kovačević
orcid.org/0000-0002-0756-8243
; Department of Chemistry and Biochemistry, Faculty of Food Technology and Biotechnology, University of Zagreb, Pierottijeva 6, 10 000 Zagreb, Croatia
Lidij Barišić
; Department of Chemistry and Biochemistry, Faculty of Food Technology and Biotechnology, University of Zagreb, Pierottijeva 6, 10 000 Zagreb, Croatia
Abstract
The emergence of COVID-19 has caused worldwide concern due to its high infectivity and mortality. Research groups around the world have prioritised drug development against COVID-19. Repurposing of already approved drugs, including the antimalarial drug chloroquine, has attracted considerable attention. The aim of this article is to (i) provide an overview of the recent chemical methods used to synthesise chloroquine and hydroxychloroquine, and (ii) provide insight into the data collected in 2020 on their efficacy against COVID-19. Unfortunately, the promising early results have not been confirmed and a clear and unambiguous conclusion on their clinical efficacy has not yet been drawn.
Keywords
chemical synthesis; chloroquine; COVID-19; hydroxychloroquine; SARS-CoV-2
Hrčak ID:
280746
URI
Publication date:
18.7.2022.
Visits: 408 *