ADMET and DMPK, Vol. 10 No. 3, 2022.
Izvorni znanstveni članak
https://doi.org/10.5599/admet.1167
Silver(I) complexes with phenolic Schiff bases: Synthesis, anti-bacterial evaluation and interaction with biomolecules
Natalia Loginova
; Faculty of Chemistry, Belarusian State University, Minsk, Belarus
Maxim Gvozdev
; Faculty of Chemistry, Belarusian State University, Minsk, Belarus
Nikolai Osipovich
; Research Institute for Physico-Chemical Problems of the Belarusian State University, Minsk, Belarus
Alina Khodosovskaya
; Faculty of Biology, Belarusian State University, Minsk, Belarus
Tatiana Koval’chuk-Rabchinskaya
; Faculty of Chemistry, Belarusian State University, Minsk, Belarus
Galina Ksendzova
; Research Institute for Physico-Chemical Problems of the Belarusian State University, Minsk, Belarus
Dzmitry Kotsikau
; Faculty of Chemistry, Belarusian State University, Minsk, Belarus
Anatoly Evtushenkov
; Faculty of Biology, Belarusian State University, Minsk, Belarus
Sažetak
Novel Ag(I) complexes (2a–2c) with phenolic Schiff bases were synthesized using 4,6-di-tert-butyl-3-(((5-mercapto-1,3,4-thiadiazol-2-yl)imino)methyl)benzene-1,2-diol (1a), 4,6-di-tert-butyl-3-(((4-mercaptophenyl)imino)methyl)benzene-1,2-diol (1b), and 4,6-di-tert-butyl-3-(((3-mercaptophenyl)imino)methyl)benzene-1,2-diol (1c). They were examined by elemental analysis, FT-IR, UV-Vis, 1H-NMR spectroscopy, XRD, cyclic voltammetry, conductivity measurements, and biological methods. The complexes are characterized by distorted geometry of the coordination cores AgN2S2 (2c), AgNS (2b) and AgS2 (2a). These stable complexes were not typified by the intramolecular redox reaction in organic solvents resulting in the formation of silver nanoparticles (AgNPs). Antibacterial activity of 1a–1c and 2a–2c was evaluated in comparison with AgNPs and commonly used antibiotics. All the complexes were more active than the ligands against the bacteria tested (14), but they were less active than AgNPs and commonly used antibiotics. Both 1a–1c and their complexes 2a–2c exhibited the capability for the bovine heart Fe(III)-Cyt c reduction. The ligands 1b and 1c were characterized by the highest reduction rate among the compounds under study, and they showed a higher reducing ability (determined by cyclic voltammetry) as compared with that of their Ag(I) complexes 2b and 2c.
Ključne riječi
Silver; Phenolic compounds; Nanoparticles; Antimicrobial activity; BSA binding; Cytochrome c reduction
Hrčak ID:
281891
URI
Datum izdavanja:
13.9.2022.
Posjeta: 305 *