Pregledni rad

https://doi.org/10.37797/ig.41.4.2

Neurological Complications of COVID-19

Inge Klupka-Sarić orcid.org/0000-0003-4704-9269 ; Klinika za neurologiju, Sveučilišna klinička bolnica Mostar, Mostar, Bosna i Hercegovina
Jurica Arapović orcid.org/0000-0002-7674-6795 ; Klinika za infektivne bolesti, Sveučilišna klinička bolnica Mostar, Mostar, Bosna i Hercegovina
Davor Batinić orcid.org/0000-0002-0911-9628 ; Klinika za neurologiju, Sveučilišna klinička bolnica Mostar, Mostar, Bosna i Hercegovina
Nikica Šutalo orcid.org/0000-0002-8119-2352 ; Klinika za kirurgiju, Sveučilišna klinička bolnica Mostar, Mostar, Bosna i Hercegovina
Azer Rizikalo ; Klinika za urologiju, Sveučilišna klinička bolnica Mostar, Mostar, Bosna i Hercegovina
Anita Ivanković ; Klinika za neurologiju, Sveučilišna klinička bolnica Mostar, Mostar, Bosna i Hercegovina
Sandra Lakičević orcid.org/0000-0002-0260-8330 ; Klinika za neurologiju, Sveučilišna klinička bolnica Mostar, Mostar, Bosna i Hercegovina
Matea Baranik orcid.org/0000-0001-8250-1762 ; Klinika za neurologiju, Sveučilišna klinička bolnica Mostar, Mostar, Bosna i Hercegovina

Sažetak

Coronavirus disease in 2019 (COVID-19) is caused by the newly discovered coronavirus type 2 which causes severe acute respiratory syndrome (SARS-CoV-2). The virus was discovered in December 2019, and the World Health Organization has declared a pandemic due to the number of cases and the spread around the world. The clinical presentation of COVID-19 varies from asymptomatic to severe and lethal outcome. Although the clinical picture is dominated by respiratory disorders, numerous studies indicate the occurrence of acute and chronic neurological complications in almost a third of patients. The most common neurological symptoms of the acute phase of COVID-19 are headache, loss of smell and taste, disturbances of consciousness, encephalopathies, encephalitis, stroke, muscle pain, epileptic seizures, polyradiculopathy (GBS) and increased fatigue and intolerance to stressful and mental disorders in the postinfectious phase of the disease. Potential pathophysiological mechanisms of the development of neurological disorders in the acute phase include coagulopathies with associated hypoxic-ischemic damage, blood-brain barrier disorder, endotheliopathies and neuroinvasion of viruses with associated neuro-immune response.
The objective of this paper is to present the most common acute and chronic neurological disorders related to COVID-19 in adult patients as well as the potential pathophysiological mechanism of neurological disorders, and future epidemiological studies on patients with COVID-19 should determine the true incidence of specific neurological syndromes, to establish diagnostic and therapeutic protocols and to clarify the mechanism of disorder development.

Ključne riječi

COVID-19; headache; anosmia; stroke; encephalopathy; cognitive impairment

Hrčak ID:

284363

URI

https://hrcak.srce.hr/284363

Datum izdavanja:

28.10.2022.

Podaci na drugim jezicima: hrvatski

Posjeta: 2.538 *