Izvorni znanstveni članak

https://doi.org/10.20471/acc.2022.61.02.06

Histopathologic Parameters of Positive Lymph Node Predictability in Endometrial Cancer

Aljoša Mandić orcid.org/0000-0002-6719-8694 ; University of Novi Sad, Faculty of Medicine, Novi Sad, Serbia; Oncology Institute of Vojvodina, Novi Sad, Serbia
Dunja Kokanov ; Oncology Institute of Vojvodina, Novi Sad, Serbia
Slobodan Maričić ; Oncology Institute of Vojvodina, Novi Sad, Serbia
Tatjana Ivković Kapicl ; University of Novi Sad, Faculty of Medicine, Novi Sad, Serbia; Oncology Institute of Vojvodina, Novi Sad, Serbia
Nenad Šolajić ; University of Novi Sad, Faculty of Medicine, Novi Sad, Serbia; Oncology Institute of Vojvodina, Novi Sad, Serbia

Sažetak

Endometrial cancer is the most common malignancy of the female reproductive
tract. Lymph node metastases are an important prognostic factor in endometrial cancer. Several
prognostic factors have been shown to correlate with lymph node metastasis, including depth of myometrial
invasion, cervical infiltration, histologic grade of the tumor, tumor diameter, histology type,
lymphovascular invasion, and positive peritoneal cytology. The aim of the study was to identify the histopathologic
parameters that would indicate with greater certainty the possibility of metastases into
lymph nodes, which would serve as a basis to assess whether patients should undergo lymphadenectomy
or not. This retrospective study included patients with endometrial cancer having undergone
surgery at the Oncology Institute of Vojvodina during the 2012-2018 period. The study included 120
patients having undergone hysterectomy with bilateral adnexectomy and pelvic lymphadenectomy.
Among patients who had lymph node metastases, there were statistically significantly more patients
(p<0.01) with endometrial cancer histologic type 2, depth of myometrial invasion greater than 50%,
cervical stroma infiltration, lymphovascular invasion, and positive peritoneal cytology. In conclusion,
histopathologic parameters such as type 2 endometrial cancer, myometrial invasion depth greater than
50%, cervical stroma infiltration, lymphovascular invasion and positive peritoneal cytology increased
the likelihood of lymph node metastases. Tumor size (>2 cm), as well as histologic grade did not correlate
with a higher incidence of lymph node metastases. In this study, both parametrial infiltration
and the number of lymph nodes removed were found to have clinical relevance but not statistical
significance.

Ključne riječi

Endometrial cancer; Lymphadenectomy; Lymph node metastases

Hrčak ID:

284673

URI

https://hrcak.srce.hr/284673

Datum izdavanja:

1.8.2022.

Podaci na drugim jezicima: hrvatski

Posjeta: 702 *