Acta clinica Croatica, Vol. 61. No. 2, 2022.
Izvorni znanstveni članak
https://doi.org/10.20471/acc.2022.61.02.11
Thyroid Dysfunction in Pregnancy: Comparison of Outcomes in Infants
Zrinka Djukić Koroljević
orcid.org/0000-0001-7737-2599
; St. Catherine Specialty Hospital, Zagreb, Croatia; Faculty of Kinesiology, University of Zagreb, Zagreb, Croatia
Erina-Leona Cetinić
; Zagreb Health Center, Zagreb, Croatia
Valentina Matijević
; Department of Rheumatology, Physical Medicine and Rehabilitation, Sestre milosrdnice University Hospital Center, Zagreb, Croatia; School of Medicine, University of Zagreb, Zagreb, Croatia; Faculty of Medicine in Osijek, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia
Sažetak
The aim of this study was to compare the incidence of mild psychomotor delay in
infants whose mothers were treated for thyroid dysfunction regardless of the cause during first trimester
of pregnancy with those whose mothers did not use medications prenatally. The sample included
200 infants up to 4 months of age. Half of the infants were examined by a pediatric physiatrist, while
the other half were chosen randomly from the primary pediatric clinic. Binary logistic regression was
performed to assess the impact of factors on psychomotor delay. The model contained seven independent
variables derived from bivariate analyses and clinical relevance. Results showed that the infant’s
chance of having psychomotor delay was 5.53 times higher if the mother had drug-compensated
thyroid dysfunction. Younger gestational age increased the likelihood of delay 2.12 times per each gestational
week. The likelihood of psychomotor delay also rose by 1% per 1 g of birth weight reduction.
We found strong positive linear correlation between maternal drug-compensated thyroid dysfunction
during pregnancy and psychomotor delay in infants, which has not been reported elsewhere. This differentiates
an important and common prenatal risk factor and lays the foundation for faster initiation
of habilitation of infants at risk. These insights provide a basis for planning the National Screening
Program for Neurorisk Infants.
Ključne riječi
Habilitation; Infants; Neurodevelopmental delay; Psychomotor delay; Thyroid dysfunction
Hrčak ID:
284740
URI
Datum izdavanja:
1.8.2022.
Posjeta: 553 *