Pregledni rad
https://doi.org/10.20471/acc.2021.60.s3.02
Quality of life in patients with epilepsy – single centre experience
Andreja Bujan Kovač
; Department of Neurology, Zagreb University Hospital Centre, School of Medicine, University of Zagreb, Referral Centre of the Ministry of Health of the Republic of Croatia for Epilepsy, Affiliated Partner of the ERN EpiCARE, Zagreb, Croatia
Željka Petelin Gadže
; Department of Neurology, Zagreb University Hospital Centre, School of Medicine, University of Zagreb, Referral Centre of the Ministry of Health of the Republic of Croatia for Epilepsy, Affiliated Partner of the ERN EpiCARE, Zagreb, Croatia
Katarina Ivana Tudor
; Department of Neurology, Zagreb University Hospital Centre, School of Medicine, University of Zagreb, Referral Centre of the Ministry of Health of the Republic of Croatia for Epilepsy, Affiliated Partner of the ERN EpiCARE, Zagreb, Croatia
Sibila Nanković
; Department of Neurology, Zagreb University Hospital Centre, School of Medicine, University of Zagreb, Referral Centre of the Ministry of Health of the Republic of Croatia for Epilepsy, Affiliated Partner of the ERN EpiCARE, Zagreb, Croatia
Vlatko Šulentić
; Department of Neurology, Zagreb University Hospital Centre, School of Medicine, University of Zagreb, Referral Centre of the Ministry of Health of the Republic of Croatia for Epilepsy, Affiliated Partner of the ERN EpiCARE, Zagreb, Croatia
Zdravka Poljaković
; Department of Neurology, Zagreb University Hospital Centre, School of Medicine, University of Zagreb, Referral Centre of the Ministry of Health of the Republic of Croatia for Epilepsy, Affiliated Partner of the ERN EpiCARE, Zagreb, Croatia
Goran Mrak
; Department of Neurosurgery, Zagreb University Hospital Centre, School of Medicine, University of Zagreb, Affiliated Partner of EUROCAN, Zagreb, Croatia
Monika Mudrovčić
; Dr. Fran Mihaljević University Hospital for Infectious Diseases, Zagreb, Croatia
Ira Brezak
; Klinički studio, Private Psychology Practice, Zagreb, Croatia
Dragana Mijatović
; Istrian Health Centre, Umag Section, Umag, Croatia
Filip Đerke
; Department of Neurology, Dubrava University Hospital, School of Medicine, University of Zagreb, Zagreb, Croatia
Andrej Desnica
; Department of Neurosurgery, Zagreb University Hospital Centre, School of Medicine, University of Zagreb, Affiliated Partner of EUROCAN, Zagreb, Croatia
Jakob Nemir
; Department of Neurosurgery, Zagreb University Hospital Centre, School of Medicine, University of Zagreb, Affiliated Partner of EUROCAN, Zagreb, Croatia
Ivana Čajić
; Sveti Ivan Psychiatric Hospital, Zagreb, Croatia
Petra Nimac Kozina
; Department of Neurology, Zagreb University Hospital Centre, School of Medicine, University of Zagreb, Referral Centre of the Ministry of Health of the Republic of Croatia for Epilepsy, Affiliated Partner of the ERN EpiCARE, Zagreb, Croatia
Biljana Đapić Ivančić
; Department of Neurology, Zagreb University Hospital Centre, School of Medicine, University of Zagreb, Referral Centre of the Ministry of Health of the Republic of Croatia for Epilepsy, Affiliated Partner of the ERN EpiCARE, Zagreb, Croatia
Borislav Radić
; Department of Neurology, Zagreb University Hospital Centre, School of Medicine, University of Zagreb, Referral Centre of the Ministry of Health of the Republic of Croatia for Epilepsy, Affiliated Partner of the ERN EpiCARE, Zagreb, Croatia
Sanja Hajnšek
; Department of Neurology, Zagreb University Hospital Centre, School of Medicine, University of Zagreb, Referral Centre of the Ministry of Health of the Republic of Croatia for Epilepsy, Affiliated Partner of the ERN EpiCARE, Zagreb, Croatia
Sažetak
A prospective study was carried out at the Zagreb University Hospital Centre to
evaluate the relationship between epilepsy, antiepileptic drugs (AEDs) and quality of life (QoL) in
patients with epilepsy (PE), and its association with depressive symptoms and sexual dysfunction
(SD). QoL was assessed by use of the Quality of Life in Epilepsy-31 Inventory (QOLIE-31), SD by
the Arizona Sexual Experiences Scale (ASEX), and depressive symptoms by the Hamilton Rating
Scale for Depression (HAM-D17). The study included 108 PE (women 63% and men 37% men),
mean age 39.54±15.91 years. Focal type epilepsy was diagnosed in 14.8%, generalized type in 35.2%,
and both types were present in 40.7% of study patients. Drug-resistant epilepsy (DRE) was present in
44/108 and vagus nerve stimulation (VNS) was implanted in 27/44 patients. The mean response on
QOLIE-31 was 62.88±17.21 with no significant differences according to gender, type of epilepsy, and
age. A statistically significantly lower QoL was found in the ‘Overall QoL’ domain (35-55 vs. <35 age
group). Patients taking both types of AEDs had a significantly lower QoL compared to those on
newer types of AEDs. Higher QoL was associated with less pronounced depressive symptoms
(p=0.000). Significant correlations were found between lower QoL and SD (p=0.001). In 27 patients
with DRE having undergone VNS, a favorable effect of VNS implantation on the QoL and mood was
observed as compared with 18 patients without VNS (p=0.041).
Ključne riječi
Epilepsy; Quality of life; Antiepileptic drugs; QOLIE-31; Drug-resistant epilepsy; Vagus nerve stimulation
Hrčak ID:
285124
URI
Datum izdavanja:
31.12.2021.
Posjeta: 1.996 *