Pregledni rad

https://doi.org/10.20471/acc.2021.60.s3.02

Kvaliteta života bolesnika s epilepsijom - naša iskustva

Andreja Bujan Kovač ; Department of Neurology, Zagreb University Hospital Centre, School of Medicine, University of Zagreb, Referral Centre of the Ministry of Health of the Republic of Croatia for Epilepsy, Affiliated Partner of the ERN EpiCARE, Zagreb, Croatia
Željka Petelin Gadže ; Department of Neurology, Zagreb University Hospital Centre, School of Medicine, University of Zagreb, Referral Centre of the Ministry of Health of the Republic of Croatia for Epilepsy, Affiliated Partner of the ERN EpiCARE, Zagreb, Croatia
Katarina Ivana Tudor ; Department of Neurology, Zagreb University Hospital Centre, School of Medicine, University of Zagreb, Referral Centre of the Ministry of Health of the Republic of Croatia for Epilepsy, Affiliated Partner of the ERN EpiCARE, Zagreb, Croatia
Sibila Nanković ; Department of Neurology, Zagreb University Hospital Centre, School of Medicine, University of Zagreb, Referral Centre of the Ministry of Health of the Republic of Croatia for Epilepsy, Affiliated Partner of the ERN EpiCARE, Zagreb, Croatia
Vlatko Šulentić ; Department of Neurology, Zagreb University Hospital Centre, School of Medicine, University of Zagreb, Referral Centre of the Ministry of Health of the Republic of Croatia for Epilepsy, Affiliated Partner of the ERN EpiCARE, Zagreb, Croatia
Zdravka Poljaković ; Department of Neurology, Zagreb University Hospital Centre, School of Medicine, University of Zagreb, Referral Centre of the Ministry of Health of the Republic of Croatia for Epilepsy, Affiliated Partner of the ERN EpiCARE, Zagreb, Croatia
Goran Mrak ; Department of Neurosurgery, Zagreb University Hospital Centre, School of Medicine, University of Zagreb, Affiliated Partner of EUROCAN, Zagreb, Croatia
Monika Mudrovčić ; Dr. Fran Mihaljević University Hospital for Infectious Diseases, Zagreb, Croatia
Ira Brezak ; Klinički studio, Private Psychology Practice, Zagreb, Croatia
Dragana Mijatović ; Istrian Health Centre, Umag Section, Umag, Croatia
Filip Đerke ; Department of Neurology, Dubrava University Hospital, School of Medicine, University of Zagreb, Zagreb, Croatia
Andrej Desnica ; Department of Neurosurgery, Zagreb University Hospital Centre, School of Medicine, University of Zagreb, Affiliated Partner of EUROCAN, Zagreb, Croatia
Jakob Nemir ; Department of Neurosurgery, Zagreb University Hospital Centre, School of Medicine, University of Zagreb, Affiliated Partner of EUROCAN, Zagreb, Croatia
Ivana Čajić ; Sveti Ivan Psychiatric Hospital, Zagreb, Croatia
Petra Nimac Kozina ; Department of Neurology, Zagreb University Hospital Centre, School of Medicine, University of Zagreb, Referral Centre of the Ministry of Health of the Republic of Croatia for Epilepsy, Affiliated Partner of the ERN EpiCARE, Zagreb, Croatia
Biljana Đapić Ivančić ; Department of Neurology, Zagreb University Hospital Centre, School of Medicine, University of Zagreb, Referral Centre of the Ministry of Health of the Republic of Croatia for Epilepsy, Affiliated Partner of the ERN EpiCARE, Zagreb, Croatia
Borislav Radić ; Department of Neurology, Zagreb University Hospital Centre, School of Medicine, University of Zagreb, Referral Centre of the Ministry of Health of the Republic of Croatia for Epilepsy, Affiliated Partner of the ERN EpiCARE, Zagreb, Croatia
Sanja Hajnšek ; Department of Neurology, Zagreb University Hospital Centre, School of Medicine, University of Zagreb, Referral Centre of the Ministry of Health of the Republic of Croatia for Epilepsy, Affiliated Partner of the ERN EpiCARE, Zagreb, Croatia

Sažetak

Provedeno je prospektivno istraživanje u KBC-u Zagreb s ciljem procjene povezanosti epilepsije, antiepileptičkih lijekova
(antiepileptic drug, AED) i kvalitete života (quality of life, QoL) u bolesnika s epilepsijom, kao i učestalosti depresije i
seksualne disfunkcije (SD). QOLIE-31 (Quality of Life in Epilepsy-31 Inventory) je primijenjen za procjenu QoL-a, ASEX
(Arizona Sexual Experiences Scale) za SD i HAM-D17 (Hamilton Rating Scale) za depresiju. Uključeno je 108 bolesnika s
epilepsijom (63% žena, 37% muškaraca; srednja dob 39,54±15,91 godina). Žarišnu epilepsiju imalo je 14,8% i generaliziranu
35,2% bolesnika, dok je obje vrste epilepsije imalo 40,7% bolesnika. Farmakorezistentnu epilepsiju (drug-resistant epilepsy,
DRE) imalo je 44/108 bolesnika, a kod njih 27/44 ugrađen je stimulator vagusnog živca (vagus nerve stimulation, VNS).
Srednji odgovor na QOLIE-31 bio je 62,88±7,21 bez značajnih razlika u odnosu na spol, vrstu epilepsije i dob. Statistički
značajno niži QoL nađen je u domeni ‘Sveukupni QoL’ (dobna skupina 35-55 godina u odnosu na dobnu skupinu <35).
Bolesnici koji su uzimali obje vrste AED imali su značajno niži QoL u usporedbi s onima na novijim AED. Viši QoL bio je
povezan s manje izraženim simptomima depresije (p=0,000). Pronađene su značajne korelacije između nižeg QoL-a i SD
(p=0,001). U bolesnika s DRE utvrđen je pozitivan utjecaj ugradnje VNS-a na QoL i raspoloženje (27 bolesnika s VNS-om
u usporedbi s 18 bolesnika bez VNS-a, p=0,041).

Ključne riječi

Epilepsija; Kvaliteta života; Antiepileptički lijekovi; QOLIE-31; Farmakorezistentna epilepsija; Stimulator vagusnog živca

Hrčak ID:

285124

URI

https://hrcak.srce.hr/285124

Datum izdavanja:

31.12.2021.

Podaci na drugim jezicima: engleski

Posjeta: 981 *