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False-Positive Result of a Confirmatory Human Immunodeficiency Virus Line Immuno Assay in an Apparently Healthy Individual – A Case Report

Katja Seme
Božena Kotnik-Kevorkijan
Zvonko Baklan
Kristina Fujs
Dunja Z. Babič
Mario Poljak

Puni tekst: engleski pdf 111 Kb

str. 43-46

preuzimanja: 1.820



A case of a false-positive result of human immunodeficiency virus (HIV) confirmatory immunoblot-based assay is described.
Repeatedly borderline reactive anti-HIV screening enzyme immunoassay result obtained in a local hospital resulted
in directing the sample to the Slovenian HIV/AIDS Reference Laboratory. In the Reference Laboratory, both anti-
HIV screening assays and confirmatory Western blot were negative, while a confirmatory test INNO-LIA HIV I/II Score
(Innogenetics, Ghent, Belgium) was anti-HIV-1 positive due to sgp120 and gp41 reactivity. The results of serological testing
of the second sample obtained three weeks later were completely identical, while in the third sample obtained 5
months later, seroreversion was observed. Due to a negative dynamics in anti-HIV serological profile and repeatedly negative
results of the molecular tests for HIV-1 and HIV-2, HIV infection was excluded and the results of test INNO-LIA
HIV I/II Score were finally interpreted as false positive.

Ključne riječi

HIV-1, diagnosis, false-positive result, confirmatory assays, line immuno assay

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