Izvorni znanstveni članak

https://doi.org/10.24099/vet.arhiv.1756

Alternations of cardiac biomarkers in White Pekin ducks intoxicated with arsenic and its amelioration by use of ginger

Santosh Kumar Panda ; Department of Veterinary Clinical Medicine, Ethics and Jurisprudence. College of Veterinary Science and Animal Husbandry, Odisha University of Agriculture and Technology, Bhubaneswar, India
Dhirendra Kumar ; Regional centre ICAR-Directorate of Poultry Research, Bhubaneswar, Odisha India
Geeta Rani Jena ; Department of Veterinary Clinical Medicine, Ethics and Jurisprudence. College of Veterinary Science and Animal Husbandry, Odisha University of Agriculture and Technology, Bhubaneswar, India
Ramesh Chandra Patra ; Department of Veterinary Clinical Medicine, Ethics and Jurisprudence. College of Veterinary Science and Animal Husbandry, Odisha University of Agriculture and Technology, Bhubaneswar, India
Susen Kumar Panda ; Department of Veterinary Pathology. College of Veterinary Science and Animal Husbandry, Odisha University of Agriculture and Technology, Bhubaneswar, India
Kamdev Sethy ; Department of Animal Nutrition. College of Veterinary Science and Animal Husbandry, Odisha University of Agriculture and Technology, Bhubaneswar, India
Surya Kant Mishra ; Regional centre ICAR-Directorate of Poultry Research, Bhubaneswar, Odisha India
Bijaya Kumar Swain ; Regional centre ICAR-Directorate of Poultry Research, Bhubaneswar, Odisha India
Prafulla Kumar Naik ; Regional centre ICAR-Directorate of Poultry Research, Bhubaneswar, Odisha IndiaRegional centre ICAR-Directorate of Poultry Research, Bhubaneswar, Odisha India
Chandrakant Beura ; Regional centre ICAR-Directorate of Poultry Research, Bhubaneswar, Odisha India
Ritu Gupta ; Department of Veterinary Clinical Medicine, Ethics and Jurisprudence. College of Veterinary Science and Animal Husbandry, Odisha University of Agriculture and Technology, Bhubaneswar, India

Sažetak

Cardiotoxicity is an imperative issue in the assessment of heavy metal consumption and inorganic arsenic (As). These have a cardiotoxic effect which is evaluated by biochemical, and oxidative-antioxidant tests, and by the Nrf2- HO-1 pathway. Dried ginger powder is recognized for its efficient antioxidant activities and as a protector of the cardiovascular system from toxic damage caused by heavy metals. However, the possible function of ginger against As in heart via heme oxygenase-1 (HO-1) and nuclear factor erythroid 2-related factor (Nrf2) is unclear. A total of 120 White Pekin ducks were randomly distributed into groups comprising 24 birds in each. Each group comprised 3 replicates having 8 birds in each replicate. The time period of this study was 90 days. The groups were the control [Group I] whereas groups II to IV were fed a basal diet including arsenic at 28 mg/L. Dried ginger powder as an ameliorative agent was mixed with the basal diet and fed at 0.1, 0.3 and 1 g/kg feed to groups III, IV and V, respectively. In the current experiment, dried ginger powder decreased As-induced reactive oxygen species (ROSs) production, oxidative injury and pathological modifications. In addition, cardiac dysfunction factors, intracellular calcium (Ca2+), As accumulation and cAMP deficiency levels were noticed in ducks; these alternations were attenuated by ginger. Furthermore, ginger significantly altered the down regulation of both HO-1 and Nrf2 gene expressions caused by As. Thus, the proven protective role of ginger against As-induced cardiotoxicity may be a consequence of the maintenance of redox homeostasis, i.e. the Nrf2-HO-1 pathway and by enabling As efflux.

Ključne riječi

arsenic; duck; Nrf2-HO1 gene; cardiac biomarkers; oxidative-antioxidant

Hrčak ID:

307409

URI

https://hrcak.srce.hr/307409

Datum izdavanja:

16.8.2023.

Podaci na drugim jezicima: hrvatski

Posjeta: 586 *