Original scientific paper
https://doi.org/10.21857/y6zolb6rjm
CGRP-induced headache and hemodynamic response for prediction of therapy based on CGRP antagonism
Marjan Zaletel
orcid.org/0000-0002-5121-5621
; University Clinical Centre of Ljubljana, Ljubljana, Slovenia
Abstract
Migraine is increasingly recognized as a disorder of the calcitonin gene-related peptide (CGRP) pathway. However, other factors are involved in migraine pathophysiology such as vasoactive intestinal peptide (VIP) and PACAP-38. Indeed, the CGRP-test can discriminate migraine from non-migraine and other non-CGRP induced migraine using CGRP-induced headache (CGRP-IH) and cerebral hemodynamic changes. Recent studies support the evidence of CGRP susceptible migraine prone to CGRP antagonism. Therefore, the CGRP-test may have an important role in therapeutic decisions regarding anti-CGRP monoclonal antibodies and gepants. This may improve the clinical effects of CGRP antagonism in migraine patients and increase therapeutic adherence. From the perspective of pain medicine may improve placebo response which can enhance favourable therapeutic outcomes.
Keywords
migraine; calcitonin gene-related peptide (CGRP); transcranial Doppler (TCD); migraine susceptible to CGRP
Hrčak ID:
312711
URI
Publication date:
22.12.2023.
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